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[组蛋白乙酰化对牙周炎组织来源的牙周膜干细胞成骨分化的影响]

[Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue].

作者信息

Sun Jin, Liu Yun, Qu Qian, Qu Juan, Luo Wei, Zhang Feng, Wu Min

机构信息

Stomatology Health Care Center, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518048, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2019 Feb 1;37(1):102-105. doi: 10.7518/hxkq.2019.01.020.

Abstract

Epigenetics is defined as a change in gene expression without the alteration of the genetic sequence. Such a change would be inherited by offspring. Histone acetylation is a type of epigenetics. Existing studies proposed that chronic periodontitis is related to epigenetic modification. In this review, we summarised the influence of chronic periodontitis on periodontal ligament stem cells by histone acetylation.

摘要

表观遗传学的定义是基因表达发生变化而基因序列未改变。这种变化会遗传给后代。组蛋白乙酰化是表观遗传学的一种类型。现有研究表明,慢性牙周炎与表观遗传修饰有关。在这篇综述中,我们总结了慢性牙周炎通过组蛋白乙酰化对牙周膜干细胞的影响。

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本文引用的文献

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Histone Demethylases KDM4B and KDM6B Promote Osteogenic Differentiation of Human MSCs.
Cell Stem Cell. 2018 Dec 6;23(6):898-899. doi: 10.1016/j.stem.2018.11.002.
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