仿生源合成兰克西啶类抗生素
Biomimetic Synthesis of Lankacidin Antibiotics.
机构信息
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
University of Chinese Academy of Sciences , 19A Yuquan Road, Beijing 100049, China.
出版信息
J Am Chem Soc. 2017 Sep 20;139(37):12939-12942. doi: 10.1021/jacs.7b08500. Epub 2017 Sep 6.
PMID:28853876
Abstract
We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.
摘要
我们设计了短的合成路线来合成 lankacidinol 和 lankacyclinol，其中采用了仿生 Mannich 大环化反应。这些化合物的碳骨架的模块化构建适合于快速的结构多样化，以开发抗生素和抗肿瘤药物。
Zotero 插件