Nagasawa H, Ishida M, Mori T
Lab Anim Sci. 1987 Apr;37(2):200-2.
The relative incidence of mammary tumors with uterine adenomyosis was examined in SHN mice subjected to hormonal manipulation between 30 and 90 days of age. The incidence of mammary tumors paralleled that of adenomyosis in controls. A single pituitary grafted under the kidney capsule or progesterone pellet implanted at a young age increased the incidence of both mammary and uterine lesions. However, the pattern of long-term response to hormones was different between mammary gland and uterus. The results indicate the possible relevance of this animal model for study of the cause and management of multiple endocrine syndrome in women.
在30至90日龄接受激素处理的SHN小鼠中，研究了乳腺肿瘤与子宫腺肌病的相对发生率。对照组中乳腺肿瘤的发生率与腺肌病的发生率相似。年轻时在肾被膜下移植单个垂体或植入孕酮丸会增加乳腺和子宫病变的发生率。然而，乳腺和子宫对激素的长期反应模式不同。结果表明，该动物模型可能与研究女性多内分泌综合征的病因和治疗有关。
