Difference in response to mammotropic hormones of mammary growth and uterine adenomyosis among four strains of mice.

The effects of single pituitary grafting and treatments with progesterone or oestrogen on mammary gland growth and uterine adenomyosis were studied in four strains of female and male mice with different mammary gland growth potentials (SHN/Mei, SLN/Mei, GR/AMei and C3H/HeMei). The order of responses of different strains of mammary gland growth to hormone manipulations generally parallelled those in the intact controls, while there was some strain - related difference in response to individual hormones. The relationship between the experimental and the control groups seen in mammary gland growth was not always observed in the development and the progression of uterine adenomyosis in all strains. These results indicate that the importance of cell susceptibility to hormones in the growth is different between target tissues.