Nagasawa H, Naito T, Mori T
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
In Vivo. 1988 Mar-Apr;2(2):171-5.
The effects of single pituitary grafting and treatments with progesterone or oestrogen on mammary gland growth and uterine adenomyosis were studied in four strains of female and male mice with different mammary gland growth potentials (SHN/Mei, SLN/Mei, GR/AMei and C3H/HeMei). The order of responses of different strains of mammary gland growth to hormone manipulations generally parallelled those in the intact controls, while there was some strain - related difference in response to individual hormones. The relationship between the experimental and the control groups seen in mammary gland growth was not always observed in the development and the progression of uterine adenomyosis in all strains. These results indicate that the importance of cell susceptibility to hormones in the growth is different between target tissues.
在四种具有不同乳腺生长潜能的雌性和雄性小鼠品系（SHN/Mei、SLN/Mei、GR/AMei和C3H/HeMei）中，研究了单垂体移植以及用孕酮或雌激素处理对乳腺生长和子宫腺肌病的影响。不同品系乳腺生长对激素处理的反应顺序通常与完整对照组相似，不过对个别激素的反应存在一些品系相关差异。在所有品系中，并非总能在子宫腺肌病的发生和发展中观察到乳腺生长实验与对照组之间的关系。这些结果表明，靶组织在生长过程中细胞对激素的敏感性重要性有所不同。
