Haggie J A, Sellwood R A, Howell A, Birch J M, Schor S L
Lancet. 1987 Jun 27;1(8548):1455-7. doi: 10.1016/s0140-6736(87)92206-9.
Fetal and normal adult skin fibroblasts show distinctive migratory behaviour when plated on three-dimensional collagen gels. Skin fibroblasts from 13 of 15 patients with hereditary breast cancer showed fetal-like behaviour compared with only 1 of 12 age-matched healthy controls (p less than 0.015; Wilcoxon signed-rank matched-pairs test). In addition, 10 of 15 first-degree relatives of patients with hereditary breast cancer showed a fetal-like fibroblast phenotype, compared with none of 7 surgical controls (p less than 0.009; chi 2 test). These results suggest that abnormalities expressed by skin fibroblasts may help identify people at increased risk of breast cancer developing.
当接种到三维胶原凝胶上时，胎儿和成体正常皮肤成纤维细胞表现出独特的迁移行为。15例遗传性乳腺癌患者中有13例的皮肤成纤维细胞表现出类似胎儿的行为，而12例年龄匹配的健康对照中只有1例如此（P<0.015；Wilcoxon符号秩配对检验）。此外，遗传性乳腺癌患者的15名一级亲属中有10名表现出类似胎儿的成纤维细胞表型，而7名手术对照中无人如此（P<0.009；卡方检验）。这些结果表明，皮肤成纤维细胞所表现出的异常可能有助于识别患乳腺癌风险增加的人群。
