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载吉非替尼的 DSPE-PEG2000 纳米胶束与 CD133 适体靶向肺癌干细胞。

Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells.

机构信息

Department of Respiratory Medicine, Wuhan NO. 1 Hospital, 215 Zhongshan Street, Wuhan, 430022, China.

Laboratory Medicine, Third Hubei Provincial People's Hospital, Zhongshan Street, Wuhan, 430022, China.

出版信息

World J Surg Oncol. 2017 Aug 30;15(1):167. doi: 10.1186/s12957-017-1230-4.

DOI:10.1186/s12957-017-1230-4
PMID:28854941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5577827/
Abstract

BACKGROUND

Lung cancer stem cells (CSCs) are considered to be the seed of lung cancer, and CD133 is a marker of lung CSCs. Here, we developed gefitinib-loaded poly(ethylene glycol) 2000-distearoylphosphatidylethanolamine nanomicelles with CD133 aptamers (M-Gef-CD133) to eliminate CD133 lung CSCs.

METHODS

M-Gef-CD133 was prepared using a lipid-film-based approach. The targeting and activity of M-Gef-CD133 towards lung CSCs were evaluated.

RESULTS

M-Gef-CD133 were small (25 nm) and showed enhanced cytotoxic effect towards CD133 lung CSCs compared with non-targeted M-Gef and gefitinib. Notably, M-Gef-CD133 could significantly reduce tumor sphere formation and the percentage of CD133 lung CSCs, indicating that it possesses selective toxicity against CD133 lung CSCs.

CONCLUSIONS

The interaction of CD133 aptamers and CD133 shows promise in the delivery of gefitinib to CD133 lung CSCs, and M-Gef-CD133 represents a promising treatment to target lung CSCs.

摘要

背景

肺癌干细胞（CSCs）被认为是肺癌的种子，CD133 是肺癌 CSCs 的标志物。在这里，我们开发了载有 CD133 适体的吉非替尼聚乙二醇 2000-二硬脂酰磷脂酰乙醇胺纳米胶束（M-Gef-CD133），以消除 CD133 肺癌 CSCs。

方法

M-Gef-CD133 是采用脂质膜法制备的。评估了 M-Gef-CD133 对肺癌 CSCs 的靶向性和活性。

结果

M-Gef-CD133 粒径较小（25nm），对 CD133 肺癌 CSCs 的细胞毒性作用明显高于非靶向 M-Gef 和吉非替尼。值得注意的是，M-Gef-CD133 可显著降低肿瘤球形成和 CD133 肺癌 CSCs 的比例，表明其对 CD133 肺癌 CSCs 具有选择性毒性。

结论

CD133 适体与 CD133 的相互作用有望将吉非替尼递送至 CD133 肺癌 CSCs，M-Gef-CD133 是一种有前途的针对肺癌 CSCs 的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/dad2eb959e5a/12957_2017_1230_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/091a87789970/12957_2017_1230_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/ece6ad75f7ee/12957_2017_1230_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/d20b6c77fccf/12957_2017_1230_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/9d12f215be96/12957_2017_1230_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/dad2eb959e5a/12957_2017_1230_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/091a87789970/12957_2017_1230_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/ece6ad75f7ee/12957_2017_1230_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/d20b6c77fccf/12957_2017_1230_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/9d12f215be96/12957_2017_1230_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6730/5577827/dad2eb959e5a/12957_2017_1230_Fig5_HTML.jpg

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本文引用的文献

1
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Crit Rev Oncol Hematol. 2017 Apr;112:126-135. doi: 10.1016/j.critrevonc.2017.02.009. Epub 2017 Feb 16.
2
Nanomedicine strategies for sustained, controlled and targeted treatment of cancer stem cells.用于癌症干细胞持续、可控和靶向治疗的纳米医学策略。
Nanomedicine (Lond). 2016 Dec;11(24):3261-3282. doi: 10.2217/nnm-2016-0261. Epub 2016 Nov 17.
3
Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system.
定义转移起始细胞在促进卵巢癌发生中的作用。
Biology (Basel). 2023 Dec 5;12(12):1492. doi: 10.3390/biology12121492.
4
Busting the Breast Cancer with AstraZeneca's Gefitinib.阿斯利康的吉非替尼抗击乳腺癌
Adv Pharmacol Pharm Sci. 2023 Dec 4;2023:8127695. doi: 10.1155/2023/8127695. eCollection 2023.
5
Development of Gefitinib-Loaded Solid Lipid Nanoparticles for the Treatment of Breast Cancer: Physicochemical Evaluation, Stability, and Anticancer Activity in Breast Cancer (MCF-7) Cells.用于治疗乳腺癌的吉非替尼载药固体脂质纳米粒的研发：物理化学评估、稳定性及对乳腺癌（MCF-7）细胞的抗癌活性
Pharmaceuticals (Basel). 2023 Nov 2;16(11):1549. doi: 10.3390/ph16111549.
6
Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets.揭开癌症干细胞的欺骗性本质：CD133 在揭示其秘密中的作用。
Int J Mol Sci. 2023 Jun 30;24(13):10910. doi: 10.3390/ijms241310910.
7
Clinical relevance of stem cells in lung cancer.干细胞在肺癌中的临床相关性。
World J Stem Cells. 2023 Jun 26;15(6):576-588. doi: 10.4252/wjsc.v15.i6.576.
8
DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors.基于DNA的纳米材料作为药物递送平台以增强药物在肿瘤中的疗效。
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用于消化系统癌症干细胞持续、可控和靶向治疗的纳米医学策略。
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4
New and emerging targeted treatments in advanced non-small-cell lung cancer.晚期非小细胞肺癌的新型和新兴靶向治疗方法。
Lancet. 2016 Sep 3;388(10048):1012-24. doi: 10.1016/S0140-6736(16)31473-8. Epub 2016 Sep 1.
5
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Transl Lung Cancer Res. 2016 Jun;5(3):272-9. doi: 10.21037/tlcr.2016.02.01.
6
Progression and metastasis of lung cancer.肺癌的进展与转移
Cancer Metastasis Rev. 2016 Mar;35(1):75-91. doi: 10.1007/s10555-016-9618-0.
7
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CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32. doi: 10.3322/caac.21338. Epub 2016 Jan 25.
8
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9
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10
Nanomedicine for treatment of cancer stem cells.用于治疗癌症干细胞的纳米医学。
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