新抗原图谱对成人和儿童癌症的临床意义。

Clinical implications of neoepitope landscapes for adult and pediatric cancers.

作者信息

Feng Yang-Yang, Griffith Obi L, Griffith Malachi

机构信息

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Genome Med. 2017 Aug 31;9(1):77. doi: 10.1186/s13073-017-0470-9.

DOI:10.1186/s13073-017-0470-9

PMID:28854952

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5577778/

Abstract

Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers.See related research article 10.1186/s13073-017-0468-3.

摘要

许多免疫疗法依赖于源自体细胞突变的新抗原的存在，这些突变会导致肽序列改变。目前已有多项研究分析了不同癌症亚型的新抗原图谱，主要针对成人样本，这些样本往往具有显著更高的突变负荷。然而，一份发布了对儿科新抗原图谱首次全面分析的新报告表明，免疫疗法对儿科癌症也可能具有前景。见相关研究文章10.1186/s13073-017-0468-3。