Department of Pediatric Cardiology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, India.
Department of Public Health Research, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, India.
Arch Dis Child. 2018 Feb;103(2):170-175. doi: 10.1136/archdischild-2017-313165. Epub 2017 Aug 30.
There are limited data on health-related quality of life (HRQOL) for infants and toddlers with congenital heart disease (CHD). We sought to compare generic HRQOL of infants and toddlers between CHD subjects and controls.
Dual-setting, cross-sectional analytical survey.
We collected HRQOL data on infants and toddlers through a community survey for controls and through a hospital-based survey for those with CHD.
A total of 499 subjects with confirmed CHD in the age group of 1-24 months admitted for elective surgery in the study institution were selected by consecutive sampling. In addition, we selected 628 control children in the same age group from an area within the 10 km radius of the study institution.
The data contain parent proxy report of HRQOL. The Pediatric Quality of Life Inventory (PedsQL 4.0) was used to collect HRQOL data. Questionnaires were self-administered for parents.
The mean total proxy HRQOL scores were significantly higher in control infants compared with infants with CHD (adjusted mean difference 5.0, 99% CI 2.5 to 7.5, p<0.001). Corresponding figure for toddlers was 7.6 (95% CI 5.0 to 10.2, p<0.001). There was no significant difference in total HRQOL scores across CHD functional classes among infants and toddlers (p=0.212 and p=0.502, respectively).
Infants and toddlers with uncorrected CHD have significant deficiency in proxy HRQOL compared with their controls. The functional class of CHD appears to have no differential impact on overall HRQOL deficiency in this age group.
先天性心脏病（CHD）患儿的健康相关生活质量（HRQOL）数据有限。我们旨在比较 CHD 患儿和对照组婴儿及幼儿的通用 HRQOL。
双设定、横断面分析性调查。
我们通过社区调查收集对照组婴儿及幼儿的 HRQOL 数据，并通过医院调查收集 CHD 患儿的 HRQOL 数据。
通过连续抽样，选择研究机构内年龄在 1-24 个月的 499 例确诊为 CHD 的患者，选择年龄在研究机构 10 公里半径范围内的 628 例对照儿童。
数据包含父母代表报告的 HRQOL。采用儿科生存质量量表（PedsQL 4.0）收集 HRQOL 数据。家长自行填写问卷。
与 CHD 患儿相比，对照组婴儿的平均总代表 HRQOL 评分显著更高（校正平均差异 5.0，99%可信区间 2.5 至 7.5，p<0.001）。幼儿的相应数字为 7.6（95%可信区间 5.0 至 10.2，p<0.001）。婴儿和幼儿的 CHD 功能类别之间的总 HRQOL 评分无显著差异（分别为 p=0.212 和 p=0.502）。
与对照组相比，未经矫正的 CHD 婴儿及幼儿在代表 HRQOL 方面存在明显不足。CHD 的功能类别似乎对该年龄组的整体 HRQOL 不足没有差异影响。
