Robertson D A, Zhang S L, Guy E C, Wright R
Lancet. 1987 Jul 4;2(8549):9-11. doi: 10.1016/s0140-6736(87)93051-0.
A radiolabelled 50-base oligonucleotide complementary with the measles virus gene encoding the nucleocapsid was used as a probe to identify persistent measles virus genome in the lymphocytes from patients with autoimmune chronic active hepatitis (AICAH). Positive hybrids were found in 12 of 18 patients, and correlated strongly with high antibody titres to measles. Among the 45 controls, positive hybrids were found in 1 patient with measles, 1 of 3 patients with systemic lupus erythematosus, and 2 of 4 patients with cryptogenic cirrhosis. Persistence of part of the measles virus genome in AICAH may have important implications in the pathogenesis of the liver disease, and possibly in other disorders such as systemic lupus erythematosus, multiple sclerosis, and Paget's disease where an abnormal immune response to measles has been observed.
一种与编码核衣壳的麻疹病毒基因互补的放射性标记50碱基寡核苷酸被用作探针，以鉴定自身免疫性慢性活动性肝炎（AICAH）患者淋巴细胞中的持续性麻疹病毒基因组。18例患者中有12例发现阳性杂交信号，且与高滴度麻疹抗体密切相关。在45名对照者中，1例麻疹患者、3例系统性红斑狼疮患者中的1例以及4例隐源性肝硬化患者中的2例发现阳性杂交信号。AICAH中部分麻疹病毒基因组的持续存在可能对肝病的发病机制具有重要意义，并且可能对其他疾病如系统性红斑狼疮、多发性硬化症和佩吉特病也有重要意义，在这些疾病中已观察到对麻疹的异常免疫反应。
