Sommer A I, Haukenes G
J Clin Pathol. 1982 Dec;35(12):1388-91. doi: 10.1136/jcp.35.12.1388.
A majority of patients with HBsAg-negative chronic active hepatitis (CAH) show considerably raised titres of serum antibodies against measles virus antigens. Since these patients often have high titers of antiactin specific antibodies against smooth muscle, and since actin is also incorporated into the measles virion during replication, we have examined whether there was any cross-reactivity between the two antigen-antibody systems. Cross-absorptions of sera from patients with CAH were performed using measles virus antigens and smooth muscle from human uterus. The corresponding specific antibodies were removed from serum without significantly affecting the titres of the other antibodies. Absorption had no influence on the total amount of IgG in serum. The raised titres of antibodies against measles virus seen in CAH can therefore not be explained by cross-reaction with antibodies to smooth muscle.
大多数乙肝表面抗原阴性的慢性活动性肝炎（CAH）患者血清中抗麻疹病毒抗原的抗体滴度显著升高。由于这些患者通常具有高滴度的抗平滑肌肌动蛋白特异性抗体，且肌动蛋白在复制过程中也会整合到麻疹病毒粒子中，因此我们研究了这两种抗原-抗体系统之间是否存在交叉反应。使用麻疹病毒抗原和人子宫平滑肌对CAH患者的血清进行交叉吸收。相应的特异性抗体从血清中去除，而不会显著影响其他抗体的滴度。吸收对血清中IgG的总量没有影响。因此，CAH中出现的抗麻疹病毒抗体滴度升高不能用与抗平滑肌抗体的交叉反应来解释。
