Venter D J, Tuzi N L, Kumar S, Gullick W J
Lancet. 1987 Jul 11;2(8550):69-72. doi: 10.1016/s0140-6736(87)92736-x.
Amplification of the human protooncogene c-erbB-2 was found in 12 of 36 human breast tumours and was associated with increased levels of expression of the c-erbB-2 protein, measured both by immunohistological staining and by western blotting. The use of immunohistological staining to detect the level of expression of the c-erbB-2 protein in human breast adenocarcinomas may be of value in predicting tumour behaviour.
在36例人类乳腺肿瘤中，有12例发现人类原癌基因c-erbB-2发生扩增，且通过免疫组织化学染色和蛋白质印迹法检测发现，其与c-erbB-2蛋白表达水平升高相关。利用免疫组织化学染色检测人类乳腺腺癌中c-erbB-2蛋白的表达水平，可能对预测肿瘤行为具有重要价值。
