Minhas Abdul M, Nayab Asra, Iyer Shobana, Narmeen Mehek, Fatima Kaneez, Khan Muhammad S, Constantin Jonathan
Internal Medicine, Orange Park Medical Center.
Radiology, Orange Park Medical Center.
Cureus. 2017 Jun 27;9(6):e1399. doi: 10.7759/cureus.1399.
As the concerns regarding Zika virus (ZIKV) are mostly of neurological disorders, especially in neonates and infants, other possible threats of the virus may have been overlooked. Our study focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseases. We conducted a literature search of multiple terms in March 2017 using the search engines, PubMed, Embase, and SCOPUS. Articles were then reviewed by two independent reviewers, adhering strictly to our review criteria. No discriminations were made whether the studies were conducted on human or non-human subjects. Three relevant studies were shortlisted and finalized. The nature of the studies is as follows: prospective observational multicenter study (n = 9), case report (n = 1), and animal studies (n = 5). The studies suggested an association between cardiovascular complications and ZIKV in the acute phase of the infection. We recognize the limitations of our study owing to the paucity of the sample size of our literature review. However, the significant findings have also proved the dire need to conduct more research to further back the possibility of ZIKV's influence on the cardiac cells. Closely studying these associations can eventually help develop a vaccine for ZIKV in the near future.
由于对寨卡病毒（ZIKV）的担忧主要集中在神经紊乱方面，尤其是新生儿和婴儿，该病毒其他可能的威胁可能被忽视了。我们的研究聚焦于寨卡病毒可能像其他类似虫媒病毒疾病那样对心脏构成的潜在威胁。我们于2017年3月使用搜索引擎PubMed、Embase和SCOPUS对多个术语进行了文献检索。然后由两名独立评审员严格按照我们的评审标准对文章进行评审。无论研究是针对人类还是非人类受试者，均一视同仁。三项相关研究入围并最终确定。研究性质如下：前瞻性观察性多中心研究（n = 9）、病例报告（n = 1）和动物研究（n = 5）。这些研究表明在感染急性期心血管并发症与寨卡病毒之间存在关联。我们认识到由于文献综述样本量不足，我们的研究存在局限性。然而，这些重要发现也证明了迫切需要开展更多研究，以进一步支持寨卡病毒影响心脏细胞的可能性。密切研究这些关联最终可能有助于在不久的将来研发出寨卡病毒疫苗。
