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清洁间歇性导尿与经尿道留置导尿治疗阴道分娩后显性尿潴留的比较:一项多中心随机对照临床试验。

Comparison of clean intermittent and transurethral indwelling catheterization for the treatment of overt urinary retention after vaginal delivery: a multicentre randomized controlled clinical trial.

作者信息

Mulder Femke E M, Hakvoort Robert A, de Bruin Jan P, van der Post Joris A M, Roovers Jan-Paul W R

机构信息

Department of Obstetrics and Gynaecology, Academic Medical Center, Meibergdreef 9 - room H4.240, 1105 AZ, Amsterdam, The Netherlands.

Department of Obstetrics and Gynaecology, Martini Ziekenhuis, Groningen, The Netherlands.

出版信息

Int Urogynecol J. 2018 Sep;29(9):1281-1287. doi: 10.1007/s00192-017-3452-y. Epub 2017 Aug 30.

Abstract

INTRODUCTION AND HYPOTHESIS

Overt postpartum urinary retention (PUR) is the inability to void after delivery and affects up to 7% of patients. Clean intermittent catheterization (CIC) and transurethral indwelling catheterization (TIC) are both standard treatments, but have not previously been compared. Clinical guidelines on postpartum bladder management are lacking.

METHODS

A total of 85 patients were randomised for TIC (n=45) and CIC (n=40). In total 68 patients (34 patients with TIC and 34 patients with CIC) completed the UDI-6 questionnaire 3 months after delivery.. Patients allocated to TIC received an indwelling catheter for 24 h and if necessary, another catheter for 48 h. Patients with CIC were intermittently catheterized or taught to self-catheterize until adequate voiding with a postvoid residual volume (PVRV) of <150 mL was achieved. The primary outcome was the presence of bothersome micturition symptoms as measured using the Dutch-validated Urogenital Distress Inventory (UDI-6).

RESULTS

Only seven patients (10%) reported bothersome micturition problems 3 months after delivery. No significant differences in the occurrence of micturition symptoms were found. Median PVRV was 800 mL in the CIC group and 650 mL in the TIC group. PVRV was ≥1,000 mL in 24% of the patients. The median duration of catheterization was significantly shorter in the CIC group than in the TIC group (12 h vs. 24 h, p < 0,01). In patients with CIC, 35% required only one catheterization before complete bladder emptying occurred. The duration of treatment was not related to the initial PVRV. Both treatments were equally well accepted by the patients.

CONCLUSIONS

In patients with overt PUR, CIC is the preferred treatment as a considerable percentage of patients appear to be over-treated when the standard duration of TIC is 24 h. The occurrence of micturition symptoms is not associated with the catheterization method used. CIC is well tolerated in patients with overt PUR.

摘要

引言与假设

产后显性尿潴留(PUR)是指分娩后无法排尿,影响多达7%的患者。清洁间歇性导尿(CIC)和经尿道留置导尿(TIC)都是标准治疗方法,但此前尚未进行比较。缺乏关于产后膀胱管理的临床指南。

方法

总共85例患者被随机分为TIC组(n = 45)和CIC组(n = 40)。共有68例患者(34例TIC患者和34例CIC患者)在分娩后3个月完成了UDI - 6问卷。分配到TIC组的患者留置导尿管24小时,必要时再留置48小时。CIC组患者进行间歇性导尿或接受自我导尿教导,直到实现充分排尿且残余尿量(PVRV)<150 mL。主要结局是使用荷兰验证的泌尿生殖系统困扰量表(UDI - 6)测量的令人烦恼的排尿症状的存在情况。

结果

只有7例患者(10%)在分娩后3个月报告有令人烦恼的排尿问题。排尿症状的发生率未发现显著差异。CIC组患者的PVRV中位数为800 mL,TIC组为650 mL。24%的患者PVRV≥1000 mL。CIC组的导尿中位持续时间显著短于TIC组(12小时对24小时,p < 0.01)。在CIC组患者中,35%在膀胱完全排空前仅需一次导尿。治疗持续时间与初始PVRV无关。两种治疗方法在患者中接受程度相同。

结论

对于产后显性尿潴留患者,CIC是首选治疗方法,因为当TIC的标准持续时间为24小时时,相当一部分患者似乎接受了过度治疗。排尿症状的发生与所使用的导尿方法无关。CIC在产后显性尿潴留患者中耐受性良好。

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