Altieri Roberto, Zenga Francesco, Ducati Alessandro, Melcarne Antonio, Cofano Fabio, Mammi Marco, Di Perna Giuseppe, Savastano Riccardo, Garbossa Diego
Neurosurgical Unit, Department of Neuroscience, University of Turin, Turin, Italy.
AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Neurosurg Rev. 2018 Apr;41(2):599-604. doi: 10.1007/s10143-017-0899-8. Epub 2017 Aug 31.
Prognostic factors for high-grade gliomas include patient age, IDH1 mutation, MGMT methylation, and Ki67 value. We assessed the predictive role of topographic location of gliomas for their biological signatures. Collecting all neuroradiological and histological data of patients with histologically proven HGG, we performed a retrospective monocentric study. A predictive value of frontal location for a lower Ki67 value (especially in the left hemisphere) and mutation of IDH1 (especially in the right hemisphere) was found. Temporal location was predictive for IDH1 wild-type. Involvement of the parietal lobe was found to be predictive of methylated MGMT, while insular lobe involvement predicted an unmethylated MGMT. There was no statistically significant difference of IDH1 mutation and MGMT methylation between left and right sides.
高级别胶质瘤的预后因素包括患者年龄、异柠檬酸脱氢酶1（IDH1）突变、O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）甲基化以及Ki67值。我们评估了胶质瘤的地形位置对其生物学特征的预测作用。收集经组织学证实为高级别胶质瘤患者的所有神经放射学和组织学数据，我们进行了一项回顾性单中心研究。发现额叶位置对较低的Ki67值（尤其是在左半球）和IDH1突变（尤其是在右半球）具有预测价值。颞叶位置对IDH1野生型具有预测性。发现顶叶受累可预测MGMT甲基化，而岛叶受累则预测MGMT未甲基化。左右两侧之间的IDH1突变和MGMT甲基化无统计学显著差异。
