Kostev Karel, Jacob Louis, Kalder Matthias
Epidemiology, QuintilesIMS, Darmstädter Landstraße 108, 60598, Frankfurt am Main, Germany.
Department of Gynecology and Obstetrics, Philipps-University Marburg, Marburg, Germany.
Cancer Causes Control. 2017 Oct;28(10):1021-1026. doi: 10.1007/s10552-017-0948-1. Epub 2017 Aug 30.
Breast cancer (BC) and genital organ cancers (GOC) are known to have a major impact on the quality of life of patients. The aim of this study was to analyze the risk of depression, anxiety, and adjustment disorders in women in Germany with a suspected but unconfirmed diagnosis of BC or GOC in their medical history.
This study included women who received a suspected diagnosis of BC or GOC and were followed between 2007 and 2015 (index date). These women were matched (1:1:1) by age to women with a confirmed diagnosis of BC or GOC and women without a cancer diagnosis. The main outcome measure of the study was the rate of depression, anxiety, and adjustment disorder diagnoses within 3 years of the index date.
The present analysis included a total of 4,842 patients (mean age = 49.3 years). Within 3 years of the index date, 23.5% of women with a confirmed diagnosis of BC or GOC, 14.1% of those with a suspected diagnosis of BC or GOC, and 10.5% of those without a cancer diagnosis developed depression, anxiety, or an adjustment disorder (log-rank p value <0.001). Women with a suspected diagnosis of cancer were at a higher risk for these psychiatric conditions than those without a cancer diagnosis (BC and GOC: HR 1.32; BC: HR 1.21; GOC: HR 1.50).
A suspected diagnosis of BC or GOC in a woman's medical history is associated with an increased risk of developing depression, anxiety, and adjustment disorders.
众所周知，乳腺癌（BC）和生殖器官癌症（GOC）对患者的生活质量有重大影响。本研究的目的是分析德国有乳腺癌或生殖器官癌症疑似但未经确诊病史的女性患抑郁症、焦虑症和适应障碍的风险。
本研究纳入了在2007年至2015年期间（索引日期）接受乳腺癌或生殖器官癌症疑似诊断并接受随访的女性。这些女性按年龄（1:1:1）与确诊为乳腺癌或生殖器官癌症的女性以及未患癌症的女性进行匹配。该研究的主要结局指标是索引日期后3年内抑郁症、焦虑症和适应障碍的诊断率。
本分析共纳入4842例患者（平均年龄 = 49.3岁）。在索引日期后的3年内，确诊为乳腺癌或生殖器官癌症的女性中有23.5%、疑似患有乳腺癌或生殖器官癌症的女性中有14.1%以及未患癌症的女性中有10.5%出现了抑郁症、焦虑症或适应障碍（对数秩检验p值<0.001）。疑似患有癌症的女性患这些精神疾病的风险高于未患癌症的女性（乳腺癌和生殖器官癌症：风险比1.32；乳腺癌：风险比1.21；生殖器官癌症：风险比1.50）。
女性病史中乳腺癌或生殖器官癌症的疑似诊断与患抑郁症、焦虑症和适应障碍的风险增加相关。
