Kostev Karel, Lasrich Maike, Schüller Lisa, Diogo Isabel, Sesterhenn Andreas, Jacob Louis
Department of Epidemiology, IQVIA, D-60598 Frankfurt am Main, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Solingen Municipal Hospital, D-42653 Solingen, Germany.
Mol Clin Oncol. 2018 Oct;9(4):459-463. doi: 10.3892/mco.2018.1694. Epub 2018 Aug 8.
The aim of this study was to estimate the prevalence of suspected head and neck cancer (HNC) diagnoses made by otolaryngologists in a population with subsequently confirmed cancer diagnoses in Germany. This study included patients with an initial documentation of confirmed cancer diagnosis made in 137 otolaryngology practices between January 2012 and December 2016 (index date). The main outcome of the study was the prevalence of diagnoses of suspected cancer in otolaryngology practices within one year prior to the first documentation of a confirmed cancer diagnosis. The association between the defined demographic and clinical variables with diagnoses of suspected cancer was analyzed using a logistic regression model. A total of 6,446 patients received a confirmed cancer diagnosis. A total of 23.1% of the population received a diagnosis of suspected cancer within 12 months prior to the first documentation of a confirmed cancer diagnosis. Patients over the age of 50 (ORs ranging from 1.44 to 1.55) and men (OR=1.52) were more likely to receive a diagnosis of suspected cancer compared with patients aged 50 or under and women. Cancer of the pyriform sinus (OR=3.00) and cancer of the thyroid gland (OR=0.27) were associated with increased and decreased odds of a diagnosis of suspected cancer compared to laryngeal cancer respectively. Overall, approximately 23% of individuals received a diagnosis of suspected cancer within a year prior to the first documentation of confirmed HNC.
本研究的目的是估计德国耳鼻喉科医生对疑似头颈癌(HNC)的诊断在随后确诊为癌症的人群中的患病率。本研究纳入了2012年1月至2016年12月期间在137家耳鼻喉科诊所首次记录确诊癌症诊断的患者(索引日期)。该研究的主要结果是在确诊癌症诊断的首次记录前一年内,耳鼻喉科诊所中疑似癌症诊断的患病率。使用逻辑回归模型分析了定义的人口统计学和临床变量与疑似癌症诊断之间的关联。共有6446名患者被确诊为癌症。在确诊癌症诊断的首次记录前12个月内,共有23.1%的人群被诊断为疑似癌症。与50岁及以下的患者和女性相比,50岁以上的患者(比值比范围为1.44至1.55)和男性(比值比=1.52)更有可能被诊断为疑似癌症。与喉癌相比,梨状窦癌(比值比=3.00)和甲状腺癌(比值比=0.27)分别与疑似癌症诊断的几率增加和降低相关。总体而言,在确诊HNC的首次记录前一年内,约23%的个体被诊断为疑似癌症。