Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA.
Department of Psychology, University of South Carolina, 1512 Pendleton Street, Columbia, SC, 29201, USA.
J Autism Dev Disord. 2017 Nov;47(11):3646-3658. doi: 10.1007/s10803-017-3270-6.
Studying anxiety in neurogenetic syndromes may inform the intersection of biological and developmental risks, facilitating effective and targeted interventions. We longitudinally examined stranger fear in infants and toddlers with fragile X syndrome (FXS; n = 46) and typical controls (n = 33), as well as associations between observed stranger fear and rating scales of anxiety, withdrawal and autism features within FXS. Results indicated atypical facial fear in FXS, although facial fear did not index anxiety, autistic symptoms or social withdrawal. Instead, lower withdrawal was associated with decreased distress vocalizations across age, and higher autistic symptoms were associated with lower intensity escape behaviors. Early stranger fear in FXS reflects both typical and atypical dimensions and may help index emergence of social anxiety in this population.
研究神经遗传综合征中的焦虑可能有助于了解生物和发育风险的交叉点，从而促进有效和有针对性的干预。我们对脆性 X 综合征 (FXS; n = 46)患儿和典型对照组婴儿和幼儿的陌生人恐惧进行了纵向研究，以及 FXS 中观察到的陌生人恐惧与焦虑、退缩和自闭症特征的评定量表之间的关联。结果表明 FXS 存在非典型的面部恐惧，尽管面部恐惧不能预测焦虑、自闭症症状或社会退缩。相反，较低的退缩与随年龄增长而减少的痛苦发声有关，较高的自闭症症状与较低强度的逃避行为有关。FXS 中的早期陌生人恐惧反映了典型和非典型的维度，可能有助于预测该人群中社交焦虑的出现。
