Zwaigenbaum Lonnie, Bauman Margaret L, Stone Wendy L, Yirmiya Nurit, Estes Annette, Hansen Robin L, McPartland James C, Natowicz Marvin R, Choueiri Roula, Fein Deborah, Kasari Connie, Pierce Karen, Buie Timothy, Carter Alice, Davis Patricia A, Granpeesheh Doreen, Mailloux Zoe, Newschaffer Craig, Robins Diana, Roley Susanne Smith, Wagner Sheldon, Wetherby Amy
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada;
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts;
Pediatrics. 2015 Oct;136 Suppl 1(Suppl 1):S10-40. doi: 10.1542/peds.2014-3667C.
Early identification of autism spectrum disorder (ASD) is essential to ensure that children can access specialized evidence-based interventions that can help to optimize long-term outcomes. Early identification also helps shorten the stressful "diagnostic odyssey" that many families experience before diagnosis. There have been important advances in research into the early development of ASDs, incorporating prospective designs and new technologies aimed at more precisely delineating the early emergence of ASD. Thus, an updated review of the state of the science of early identification of ASD was needed to inform best practice. These issues were the focus of a multidisciplinary panel of clinical practitioners and researchers who completed a literature review and reached consensus on current evidence addressing the question "What are the earliest signs and symptoms of ASD in children aged ≤24 months that can be used for early identification?" Summary statements address current knowledge on early signs of ASD, potential contributions and limitations of prospective research with high-risk infants, and priorities for promoting the incorporation of this knowledge into clinical practice and future research.
早期识别自闭症谱系障碍(ASD)对于确保儿童能够获得基于证据的专业干预措施至关重要,这些干预措施有助于优化长期预后。早期识别还有助于缩短许多家庭在诊断之前所经历的充满压力的“诊断历程”。在ASD早期发展的研究方面已经取得了重要进展,包括前瞻性设计和旨在更精确地描绘ASD早期出现情况的新技术。因此,需要对ASD早期识别科学现状进行更新综述,以为最佳实践提供参考。这些问题是一个由临床医生和研究人员组成的多学科小组的重点,该小组完成了一项文献综述,并就解决“≤24个月儿童ASD的最早迹象和症状有哪些可用于早期识别?”这一问题的当前证据达成了共识。总结陈述阐述了关于ASD早期迹象的当前知识、对高危婴儿进行前瞻性研究的潜在贡献和局限性,以及将这些知识纳入临床实践和未来研究的优先事项。