Department of Veterinary Science, University of Pisa, Via Livornese lato monte, 56122, San Piero a Grado, Pisa, Italy.
Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
Mycotoxin Res. 2018 Mar;34(1):1-8. doi: 10.1007/s12550-017-0292-z. Epub 2017 Aug 30.
Ochratoxin A (OTA) is a secondary toxic metabolite synthesized by Aspergillus or Penicillium species, which can contaminate various crops. The International Agency for Research on Cancer (IARC) classified OTA as a group 2B possible human carcinogen. The aim of the present study was to assess OTA concentrations in tissues of wild boar (Sus scrofa L.) from Tuscany (Italy). Over a period of 2 years, samples of muscle, liver, and kidney from 48 wild boars were collected and concentrations of OTA were determined by enzymatic digestion (ED) coupled to high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The highest concentrations of OTA were found in the kidneys of the 48 wild boars analyzed. No difference in concentrations was found based on years of collection and sex while a significantly higher OTA concentration was found in the kidney of the young wild boars with respect to the adult one. Monitoring the quality of meat destined for transformation is a priority in order to decrease the possibility of toxin carry-over to humans. The present study showed that contamination of wild boar meat products by OTA represents a potential emerging source of OTA.
赭曲霉毒素 A（OTA）是曲霉属或青霉属合成的一种次级毒性代谢物，可污染各种作物。国际癌症研究机构（IARC）将 OTA 归类为 2B 组可能的人类致癌物。本研究旨在评估来自意大利托斯卡纳（Tuscany）的野猪（Sus scrofa L.）组织中的 OTA 浓度。在 2 年的时间里，采集了 48 头野猪的肌肉、肝脏和肾脏样本，并通过酶解（ED）结合高效液相色谱-荧光检测（HPLC-FLD）测定 OTA 的浓度。在所分析的 48 头野猪中，OTA 的最高浓度出现在肾脏中。基于采集年份和性别，OTA 浓度没有差异，但与成年野猪相比，年轻野猪的肾脏中 OTA 浓度明显更高。监测用于转化的肉类质量是首要任务，以降低毒素转移到人类的可能性。本研究表明，OTA 污染野猪肉类产品是 OTA 的一个潜在新兴来源。
