Iannetta Marco, Lalle Eleonora, Musso Maria, Carletti Fabrizio, Scorzolini Laura, D'Abramo Alessandra, Chinello Pierangelo, Castilletti Concetta, Ippolito Giuseppe, Capobianchi Maria R, Nicastri Emanuele
National Institute for Infectious Diseases 'Lazzaro Spallanzani', IRCCS, Rome, Italy.
Euro Surveill. 2017 Aug 24;22(34). doi: 10.2807/1560-7917.ES.2017.22.34.30600.
We describe the dynamics of dengue virus (DENV) infection in a woman in her mid-30s who developed fever after returning from Sri Lanka to Italy in April 2017. Laboratory testing demonstrated detectable DENV-RNA in plasma, urine, saliva, vaginal secretion. Persistent shedding of DENV-RNA was demonstrated in vaginal secretion, and DENV-RNA was detectable in the pelleted fraction up to 18 days from symptom onset. These findings give new insights into DENV vaginal shedding and vertical transmission.
我们描述了一名35岁左右女性的登革热病毒（DENV）感染动态，该女性于2017年4月从斯里兰卡返回意大利后出现发热症状。实验室检测显示，在血浆、尿液、唾液、阴道分泌物中可检测到DENV-RNA。阴道分泌物中证实存在DENV-RNA的持续脱落，并且从症状发作起18天内，在沉淀部分均可检测到DENV-RNA。这些发现为DENV的阴道脱落和垂直传播提供了新的见解。
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