巴比妥类药物对γ-氨基丁酸（GABA）抑制猫胃对迷走神经传入纤维刺激的兴奋性反应作用的影响。

Effects of barbiturates on the inhibitory action of GABA on excitatory response of the stomach to stimulation of vagal afferent fibers in cat.

作者信息

Okamoto T, Kurahashi K, Tsubomura T, Fujiwara M

出版信息

Life Sci. 1987 Jul 27;41(4):405-11. doi: 10.1016/0024-3205(87)90215-3.

Abstract

Effects of barbiturates on the inhibitory action of GABA to the hexamethonium-resistant excitatory response of the stomach to stimulation of the vagal afferent fibers were studied in cats. Inhibition of the hexamethonium-resistant excitatory response by GABA were compared under alpha-chloralose, alpha-chloralose-phenobarbital (PhB), and alpha-chloralose-pentobarbital (PB)-anesthesia in cats. The ID50 of GABA on the hexamethonium-resistant excitatory response was not significantly affected by PhB, but reduced by PB. Both picrotoxin and bicuculline antagonized the effects of GABA. The present experiments demonstrated that PB potentiated the inhibitory effect of GABA on the hexamethonium-resistant excitatory response of the stomach, and suggested that the potentiation by PB may be due to activation of GABA-receptor-ionophore complex.

摘要

在猫身上研究了巴比妥类药物对γ-氨基丁酸（GABA）抑制胃对迷走神经传入纤维刺激的六甲铵抵抗性兴奋反应作用的影响。在猫处于α-氯醛糖、α-氯醛糖-苯巴比妥（PhB）和α-氯醛糖-戊巴比妥（PB）麻醉状态下，比较了GABA对六甲铵抵抗性兴奋反应的抑制作用。GABA对六甲铵抵抗性兴奋反应的半数抑制浓度（ID50）不受PhB的显著影响，但受PB降低。印防己毒素和荷包牡丹碱均拮抗GABA的作用。本实验表明，PB增强了GABA对胃六甲铵抵抗性兴奋反应的抑制作用，并提示PB的增强作用可能是由于GABA受体-离子载体复合物的激活。