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GABAA-receptor-mediated inhibition of the delayed increase in intragastric pressure to stimulation of vagal afferent fibres in cats.γ-氨基丁酸A型受体介导的对猫迷走传入纤维刺激后胃内压延迟升高的抑制作用。
Br J Pharmacol. 1988 Sep;95(1):163-8. doi: 10.1111/j.1476-5381.1988.tb16560.x.
2
Effects of barbiturates on the inhibitory action of GABA on excitatory response of the stomach to stimulation of vagal afferent fibers in cat.巴比妥类药物对γ-氨基丁酸（GABA）抑制猫胃对迷走神经传入纤维刺激的兴奋性反应作用的影响。
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3
Inhibitory effects of beta-alanine on the vagal efferent and afferent excitatory responses of the stomach to stimulation of vagal trunk in cats.
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Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon.豚鼠远端结肠中由GABAA和GABAB受体介导的兴奋性和抑制性反应。
Eur J Pharmacol. 1993 Jan 12;230(2):187-93. doi: 10.1016/0014-2999(93)90801-n.
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GABAergic effects on nucleus tractus solitarius neurons receiving gastric vagal inputs.γ-氨基丁酸能对接受胃迷走神经输入的孤束核神经元的影响。
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GABAA and GABAB receptor-mediated effects in guinea-pig ileum.γ-氨基丁酸A型和B型受体介导的豚鼠回肠效应。
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本文引用的文献

1
Studies on the effects of gamma-aminobutyric acid on the isolated guinea pig ileum.
Jpn J Physiol. 1960 Apr 29;10:167-82. doi: 10.2170/jjphysiol.10.167.
2
Effects of gamma-aminobutyric acid on the isolated mammalian ileum.γ-氨基丁酸对离体哺乳动物回肠的作用。
J Physiol. 1958 Jun 18;142(1):147-64. doi: 10.1113/jphysiol.1958.sp006005.
3
gamma-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestine.γ-氨基丁酸刺激豚鼠肠道内的固有抑制性和兴奋性神经。
Eur J Pharmacol. 1980 Oct 31;67(4):461-8. doi: 10.1016/0014-2999(80)90187-9.
4
The effect of GABA antagonism on propulsive activity of the guinea-pig large intestine.γ-氨基丁酸拮抗作用对豚鼠大肠推进性活动的影响。
Eur J Pharmacol. 1981 Nov 19;76(1):111-4. doi: 10.1016/0014-2999(81)90018-2.
5
Gastric atropine-sensitive excitation by peripheral vagal stimulation after hexamethonium. Antidromic activation of afferents?六甲铵后外周迷走神经刺激引起的胃阿托品敏感兴奋。传入神经的逆向激活？
Acta Physiol Scand. 1982 Mar;114(3):433-40. doi: 10.1111/j.1748-1716.1982.tb07006.x.
6
gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum.豚鼠回肠中的γ-氨基丁酸与胆碱能传递
Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):216-20. doi: 10.1007/BF00500768.
7
GABAA- and GABAB-receptor-mediated modification of intestinal motility.γ-氨基丁酸A型和γ-氨基丁酸B型受体介导的肠道运动调节
Eur J Pharmacol. 1982 Dec 17;86(1):9-17. doi: 10.1016/0014-2999(82)90390-9.
8
Drug interactions at the GABA receptor-ionophore complex.γ-氨基丁酸（GABA）受体-离子载体复合物处的药物相互作用。
Annu Rev Pharmacol Toxicol. 1982;22:245-77. doi: 10.1146/annurev.pa.22.040182.001333.
9
Gaba induced excitatory responses in the guinea-pig small intestine are antagonized by bicuculline, picrotoxinin and chloride ion blockers.γ-氨基丁酸在豚鼠小肠中诱导的兴奋性反应受到荷包牡丹碱、印防己毒素和氯离子阻滞剂的拮抗。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Nov;317(3):257-61. doi: 10.1007/BF00503827.
10
Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.外周自主神经末梢上对荷包牡丹碱不敏感的GABA受体。
Eur J Pharmacol. 1981 Apr 24;71(1):53-70. doi: 10.1016/0014-2999(81)90386-1.

γ-氨基丁酸A型受体介导的对猫迷走传入纤维刺激后胃内压延迟升高的抑制作用。

GABAA-receptor-mediated inhibition of the delayed increase in intragastric pressure to stimulation of vagal afferent fibres in cats.

作者信息

Okamoto T, Kurahashi K, Fujiwara M, Oikawa H

机构信息

Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.

出版信息

Br J Pharmacol. 1988 Sep;95(1):163-8. doi: 10.1111/j.1476-5381.1988.tb16560.x.

DOI:10.1111/j.1476-5381.1988.tb16560.x
PMID:2851348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854144/
Abstract
  1. The possible involvement of gamma-aminobutyric acidA (GABAA)- and GABAB-receptors in the inhibitory effects of GABA on the delayed increase in intragastric pressure of the stomach to stimulation of vagal afferent fibres in cats was studied. 2. Cats were anaesthetized with pentobarbitone-gallamine and pretreated with hexamethonium. GABA inhibited the hexamethonium-resistant delayed contraction of the stomach in a dose-dependent manner. Such effects of GABA were antagonized by both bicuculline and picrotoxin. 3. Muscimol, a GABAA-receptor agonist, mimicked the inhibitory effects of GABA and the effects of muscimol were antagonized by bicuculline and picrotoxin. The ID50 of muscimol was 10 times less than that of GABA. 4. In contrast to muscimol, baclofen, a GABAB-receptor agonist did not mimic the inhibitory effects of GABA. 5. The present experiments demonstrate that GABAA-receptors are involved in the inhibitory action of GABA on the delayed contraction of the stomach to vagal afferent stimulation.
摘要
  1. 研究了γ-氨基丁酸A（GABAA）受体和GABAB受体在γ-氨基丁酸（GABA）对猫迷走传入纤维刺激引起的胃内压延迟升高的抑制作用中的可能参与情况。2. 用戊巴比妥-加拉明麻醉猫并用六甲铵预处理。GABA以剂量依赖性方式抑制六甲铵抵抗的胃延迟收缩。GABA的这种作用被荷包牡丹碱和印防己毒素拮抗。3. GABAA受体激动剂蝇蕈醇模拟了GABA的抑制作用，蝇蕈醇的作用被荷包牡丹碱和印防己毒素拮抗。蝇蕈醇的半数抑制剂量（ID50）比GABA小10倍。4. 与蝇蕈醇相反，GABAB受体激动剂巴氯芬没有模拟GABA的抑制作用。5. 本实验表明，GABAA受体参与了GABA对胃迷走传入刺激延迟收缩的抑制作用。