γ-氨基丁酸A型受体介导的对猫迷走传入纤维刺激后胃内压延迟升高的抑制作用。
GABAA-receptor-mediated inhibition of the delayed increase in intragastric pressure to stimulation of vagal afferent fibres in cats.
作者信息
Okamoto T, Kurahashi K, Fujiwara M, Oikawa H
机构信息
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
出版信息
Br J Pharmacol. 1988 Sep;95(1):163-8. doi: 10.1111/j.1476-5381.1988.tb16560.x.
Abstract
- The possible involvement of gamma-aminobutyric acidA (GABAA)- and GABAB-receptors in the inhibitory effects of GABA on the delayed increase in intragastric pressure of the stomach to stimulation of vagal afferent fibres in cats was studied. 2. Cats were anaesthetized with pentobarbitone-gallamine and pretreated with hexamethonium. GABA inhibited the hexamethonium-resistant delayed contraction of the stomach in a dose-dependent manner. Such effects of GABA were antagonized by both bicuculline and picrotoxin. 3. Muscimol, a GABAA-receptor agonist, mimicked the inhibitory effects of GABA and the effects of muscimol were antagonized by bicuculline and picrotoxin. The ID50 of muscimol was 10 times less than that of GABA. 4. In contrast to muscimol, baclofen, a GABAB-receptor agonist did not mimic the inhibitory effects of GABA. 5. The present experiments demonstrate that GABAA-receptors are involved in the inhibitory action of GABA on the delayed contraction of the stomach to vagal afferent stimulation.
摘要
- 研究了γ-氨基丁酸A（GABAA）受体和GABAB受体在γ-氨基丁酸（GABA）对猫迷走传入纤维刺激引起的胃内压延迟升高的抑制作用中的可能参与情况。2. 用戊巴比妥-加拉明麻醉猫并用六甲铵预处理。GABA以剂量依赖性方式抑制六甲铵抵抗的胃延迟收缩。GABA的这种作用被荷包牡丹碱和印防己毒素拮抗。3. GABAA受体激动剂蝇蕈醇模拟了GABA的抑制作用，蝇蕈醇的作用被荷包牡丹碱和印防己毒素拮抗。蝇蕈醇的半数抑制剂量（ID50）比GABA小10倍。4. 与蝇蕈醇相反，GABAB受体激动剂巴氯芬没有模拟GABA的抑制作用。5. 本实验表明，GABAA受体参与了GABA对胃迷走传入刺激延迟收缩的抑制作用。
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