School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.
Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
Traffic. 2017 Dec;18(12):767-775. doi: 10.1111/tra.12524. Epub 2017 Oct 10.
SNAREs are the core machinery mediating membrane fusion. In this review, we provide an update on the recent progress on SNAREs regulating membrane fusion events, especially the more detailed fusion processes dissected by well-developed biophysical methods and in vitro single molecule analysis approaches. We also briefly summarize the relevant research from Chinese laboratories and highlight the significant contributions on our understanding of SNARE-mediated membrane trafficking from scientists in China.
SNAREs 是介导膜融合的核心机制。在这篇综述中，我们提供了 SNAREs 调节膜融合事件的最新进展，特别是通过先进的生物物理方法和体外单分子分析方法解析的更详细的融合过程。我们还简要总结了中国实验室的相关研究，并强调了中国科学家在我们对 SNARE 介导的膜运输理解方面的重要贡献。
