Golkhalkhali Babak, Rajandram Retnagowri, Paliany Audra Shaleena, Ho Gwo Fuang, Wan Ishak Wan Zamaniah, Johari Che Shafini, Chin Kin Fah
Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Faculty of Medicine Dean's Office, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Asia Pac J Clin Oncol. 2018 Jun;14(3):179-191. doi: 10.1111/ajco.12758. Epub 2017 Aug 31.
Colorectal cancer patients on chemotherapy usually have elevated levels of inflammatory markers and experience numerous side effects from chemotherapy thereby leading to poor quality of life. Omega-3 fatty acid and microbial cell preparation (MCP) have been known to provide significant benefits in patients on chemotherapy. The aim of this study was to determine the effect of supplementation of omega-3 fatty acid and MCP in quality of life, chemotherapy side effects and inflammatory markers in colorectal cancer patients on chemotherapy.
A double-blind randomized study was carried out with 140 colorectal cancer patients on chemotherapy. Subjects were separated into two groups to receive either placebo or MCP [30 billion colony-forming unit (CFUs) per sachet] at a dose of two sachets daily for 4 weeks, and omega-3 fatty acid at a dose of 2 g daily for 8 weeks. Outcomes measured were quality of life, side effects of chemotherapy and levels of inflammatory markers such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein.
The supplementation with MCP and omega-3 fatty acid improved the overall quality of life and alleviated certain side effects of chemotherapy. The supplementation with MCP and omega-3 fatty acid also managed to reduce the level of IL-6 (P = 0.002). There was a significant rise in the placebo group's serum TNF-α (P = 0.048) and IL-6 (P = 0.004).
The combined supplementation with MCP and omega-3 fatty acid may improve quality of life, reduce certain inflammatory biomarkers and relieve certain side effects of chemotherapy in colorectal patients on chemotherapy.
接受化疗的结直肠癌患者通常炎症标志物水平升高，并经历化疗带来的诸多副作用，从而导致生活质量低下。已知ω-3脂肪酸和微生物细胞制剂（MCP）对接受化疗的患者有显著益处。本研究的目的是确定补充ω-3脂肪酸和MCP对接受化疗的结直肠癌患者的生活质量、化疗副作用和炎症标志物的影响。
对140例接受化疗的结直肠癌患者进行了一项双盲随机研究。受试者被分为两组，一组接受安慰剂，另一组接受MCP（每袋300亿菌落形成单位），剂量为每天两袋，持续4周，同时接受剂量为每天2克的ω-3脂肪酸，持续8周。测量的结果包括生活质量、化疗副作用以及炎症标志物如白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和C反应蛋白的水平。
补充MCP和ω-3脂肪酸改善了总体生活质量，减轻了化疗的某些副作用。补充MCP和ω-3脂肪酸还降低了IL-6水平（P = 0.002）。安慰剂组的血清TNF-α（P = 0.048）和IL-6（P = 0.004）有显著升高。
联合补充MCP和ω-3脂肪酸可能改善接受化疗的结直肠癌患者的生活质量，降低某些炎症生物标志物水平，并减轻化疗的某些副作用。
