Duboule D, Haenlin M, Galliot B, Mohier E
Mol Cell Biol. 1987 May;7(5):2003-6. doi: 10.1128/mcb.7.5.2003-2006.1987.
A mouse embryonic cDNA containing two opa-like (CAX)n repeats was isolated on the basis of its cross-hybridization with a Drosophila K10 cDNA. Such repeated sequences were present in different murine mRNAs, some of which were specifically expressed during fetal life or in different adult tissues. This suggests that, as already described for Drosophila, opa-like sequences are parts of proteins involved in ontogenic or cell-type-specific functions in vertebrates. However, unlike Drosophila, such repeated sequences were not found within the murine homeo-boxes containing genes of the Hox-1 complex.
一个含有两个类opa（CAX）n重复序列的小鼠胚胎cDNA，是基于其与果蝇K10 cDNA的交叉杂交而分离得到的。这种重复序列存在于不同的小鼠mRNA中，其中一些在胎儿期或不同的成年组织中特异性表达。这表明，正如已经在果蝇中描述的那样，类opa序列是参与脊椎动物个体发育或细胞类型特异性功能的蛋白质的组成部分。然而，与果蝇不同的是，在含有Hox-1复合体基因的小鼠同源框内未发现这种重复序列。
