Institute of Chemical Industry of Forestry Products, CAF, Nanjing, 210042, China.
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
ChemMedChem. 2017 Oct 9;12(19):1600-1609. doi: 10.1002/cmdc.201700428. Epub 2017 Sep 18.
Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N-hydroxyethylacrylamide (HEAA) in the presence of Fe O @SiO nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe O @SiO nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material. DOX-loaded hydrogels exhibited a clear capacity for pH/magnetic field dual-responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan-g-poly(PA-co-HEAA)/Fe O @SiO composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.
沙菜聚糖是一种水溶性胞外β-葡聚糖，具有极好的物理化学和生物性质，可用于水凝胶的制备。本研究通过在 Fe3O4@SiO2纳米粒子的存在下，将沙菜聚糖与 4-戊烯酸（PA）和 N-羟乙基丙烯酰胺（HEAA）接枝共聚，制备了一种新的 pH/磁场双重响应水凝胶，用于盐酸阿霉素（DOX）的释放。Fe3O4@SiO2纳米粒子的整合赋予了原始材料磁敏性。载 DOX 的水凝胶表现出明显的 pH/磁场双重响应控制药物释放能力。将 pH 降低至酸性条件或引入外磁场会增强 DOX 的释放。这种沙菜聚糖-g-聚（PA-co-HEAA）/Fe3O4@SiO2复合水凝胶是一种很有前途的药物载体，可用于磁靶向药物输送，并提高了对 A549 细胞的 DOX 细胞毒性。
