Nekulová M, Mechl Z, Kerpel-Fronius S, Skalková D, Sopková B
Neoplasma. 1987;34(2):183-8.
The sensitive parameters of tubular nephrotoxicity during 4-day chemotherapy with new combination schedule of cisplatinum and 5-fluorouracil were followed. The determinations of tubular enzymes beta-glucuronidase (GRS) and gamma-glutamyltransferase (GMT) in 24 hours urine, the excretion of creatinine and proteinuria were assayed before therapy and during 4 consecutive days of treatment. We recorded the significant increase of protein excretion and only slight increase of GMT and GRS activities after chemotherapy. The decrease of the creatinine excretion on the 3rd day of therapy was not statistically significant. Simultaneously followed serum creatinine and urea levels proved the elevation of creatinine only in 1 patient (the 1st grade according WHO classification). Our results suggest that the performed regime of chemotherapy produces only very low nephrotoxicity comparing to the 1-day administration of cisplatinum. These conclusions are confirmed also by the former examinations of GRS activities in cisplatinum therapy.
对顺铂和5-氟尿嘧啶新联合方案进行4天化疗期间肾小管肾毒性的敏感参数进行了跟踪。在治疗前和连续4天的治疗期间，测定了24小时尿液中的肾小管酶β-葡萄糖醛酸酶（GRS）和γ-谷氨酰转移酶（GMT），以及肌酐排泄和蛋白尿情况。我们记录到化疗后蛋白质排泄显著增加，而GMT和GRS活性仅略有增加。治疗第3天肌酐排泄的减少无统计学意义。同时跟踪的血清肌酐和尿素水平显示，仅1例患者肌酐升高（根据世界卫生组织分类为1级）。我们的结果表明，与顺铂1天给药相比，所实施的化疗方案产生的肾毒性非常低。顺铂治疗中GRS活性的先前检查也证实了这些结论。
