Belyavin A, Nicholson A N
Neuropharmacology. 1987 May;26(5):485-91. doi: 10.1016/0028-3908(87)90032-3.
The modulation of rapid eye movement REM sleep in man by benzodiazepines has been analysed using 366 sleep recordings with at least 3 REM periods, obtained in 25 individuals, over 9 years. Sleep-dependent and sleep-independent mechanisms are believed to control REM activity, and the effect of benzodiazepines can be explained if the sleep-dependent influence is modified. It is suggested that a negative feedback mechanism, which usually encourages the appearance of REM periods, is depressed, while a threshold and oscillator which determine the cyclical appearance of the activity, and its relation with the onset of sleep, are unaffected.
在9年时间里，对25名个体进行了366次睡眠记录分析，每次记录至少有3个快速眼动（REM）睡眠期，以此研究苯二氮䓬类药物对人类快速眼动睡眠的调节作用。睡眠依赖和非睡眠依赖机制被认为可控制快速眼动活动，如果睡眠依赖影响被改变，那么苯二氮䓬类药物的作用就可以得到解释。有人提出，通常促进快速眼动睡眠期出现的负反馈机制受到抑制，而决定该活动周期性出现及其与睡眠开始关系的阈值和振荡器未受影响。
