Borbély A A, Akerstedt T, Benoit O, Holsboer F, Oswald I
Institute of Pharmacology, University of Zürich, Switzerland.
Eur Arch Psychiatry Clin Neurosci. 1991;241(1):13-21. doi: 10.1007/BF02193749.
The effects of hypnotics on descriptive and functional aspects of electrophysiological sleep parameters are assessed in this report. Because of the arbitrary definition of some of the criteria underlying the conventional sleep stage scoring procedure, computer-aided methods of EEG analysis have become increasingly important for recording and interpreting pharmacological effects on sleep. Of particular interest are the changes of EEG slow-wave activity, since this parameter varies as a function of prior sleep and waking. Several types of interaction between hypnotics and sleep regulation are discussed, some recent pharmacological developments are highlighted, and some common problems in clinical trials are specified.
本报告评估了催眠药对睡眠电生理参数描述性和功能性方面的影响。由于传统睡眠阶段评分程序所依据的一些标准定义随意，脑电图分析的计算机辅助方法对于记录和解释药物对睡眠的作用变得越来越重要。脑电图慢波活动的变化尤其令人关注，因为该参数会根据先前的睡眠和清醒状态而变化。文中讨论了催眠药与睡眠调节之间的几种相互作用类型，强调了一些近期的药理学进展，并指出了临床试验中的一些常见问题。
