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离体肺灌注:过去、现在和未来。

Ex Vivo Lung Perfusion: Past, Present, and Future.

出版信息

ASAIO J. 2018 Mar/Apr;64(2):135-139. doi: 10.1097/MAT.0000000000000650.

DOI:10.1097/MAT.0000000000000650
PMID:28857775
Abstract

Lung transplant is the only therapy for several end-stage lung diseases; however, the number of donated lungs suitable for transplant is not sufficient, and hundreds of patients have died waiting for an organ. Ex vivo lung perfusion (EVLP) has emerged as a new technology with the potential of reconditioning human donor lungs previously unsuitable for transplantation. Since the first successful transplant of a lung treated using EVLP in the year 2000, multiple clinical trials have demonstrated, in several transplant centers around the word, the feasibility and the potential of EVLP to increase the total number of lungs available for transplant.

摘要

肺移植是治疗几种终末期肺病的唯一方法;然而,适合移植的供肺数量不足,数以百计的患者在等待器官移植时死亡。离体肺灌注 (EVLP) 作为一种新技术已经出现,它有可能对以前不适合移植的人类供肺进行再处理。自 2000 年首次成功移植使用 EVLP 治疗的肺以来,多个临床试验已经在世界各地的多个移植中心证明了 EVLP 增加可用于移植的肺总数的可行性和潜力。

相似文献

1
Ex Vivo Lung Perfusion: Past, Present, and Future.离体肺灌注:过去、现在和未来。
ASAIO J. 2018 Mar/Apr;64(2):135-139. doi: 10.1097/MAT.0000000000000650.
2
An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK.英国肺移植中供体体外肺灌注的观察性研究:DEVELOP-UK。
Health Technol Assess. 2016 Nov;20(85):1-276. doi: 10.3310/hta20850.
3
Current status and future potential of ex vivo lung perfusion in clinical lung transplantation.体外肺灌注在临床肺移植中的现状与未来潜力
Artif Organs. 2023 Nov;47(11):1700-1709. doi: 10.1111/aor.14607. Epub 2023 Jul 16.
4
Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion.在人体离体肺灌注过程中分析灌注液和支气管肺泡灌洗液中的炎症和组织损伤标志物。
Eur J Cardiothorac Surg. 2017 Mar 1;51(3):577-586. doi: 10.1093/ejcts/ezw358.
5
Normothermic machine perfusion of donor-lungs ex-vivo: promoting clinical adoption.供体肺的体外常温机器灌注:促进临床应用。
Curr Opin Organ Transplant. 2020 Jun;25(3):285-292. doi: 10.1097/MOT.0000000000000765.
6
Ex-vivo lung perfusion: the model for the organ reconditioning hub.体外肺灌注:器官修复中心的模型
Curr Opin Organ Transplant. 2017 Jun;22(3):287-289. doi: 10.1097/MOT.0000000000000404.
7
Incorporating ex-vivo lung perfusion into the UK adult lung transplant service: an economic evaluation and decision analytic model.将体外肺灌注纳入英国成人肺移植服务:一项经济评估与决策分析模型
BMC Health Serv Res. 2019 May 22;19(1):326. doi: 10.1186/s12913-019-4154-6.
8
Transplantation after ex vivo lung perfusion: A midterm follow-up.体外肺灌注后移植:中期随访。
J Heart Lung Transplant. 2016 Nov;35(11):1303-1310. doi: 10.1016/j.healun.2016.05.021. Epub 2016 May 31.
9
Early results in transplantation of initially rejected donor lungs after ex vivo lung perfusion: a case-control study.体外肺灌注后最初被排斥的供体肺移植的早期结果:一项病例对照研究。
Eur J Cardiothorac Surg. 2014 Jan;45(1):40-4; discussion 44-5. doi: 10.1093/ejcts/ezt250. Epub 2013 May 10.
10
Ex vivo lung perfusion: a comprehensive review of the development and exploration of future trends.离体肺灌注:发展与未来趋势探索的全面综述。
Transplantation. 2013 Sep;96(6):509-18. doi: 10.1097/TP.0b013e318295eeb7.

引用本文的文献

1
Decreasing blood wastage during ex vivo lung perfusion recovery through utilization of thermal control technology.通过利用热控技术减少体外肺灌注恢复过程中的血液浪费。
J Card Surg. 2022 Dec;37(12):5011-5018. doi: 10.1111/jocs.17147. Epub 2022 Nov 9.
2
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center.在中国某一中心实施脑死亡后捐献后的肺移植等待患者的结局。
Front Med. 2022 Oct;16(5):760-765. doi: 10.1007/s11684-021-0899-5. Epub 2022 Jul 1.
3
Is there life on the airway tree? A pilot study of bronchial cell vitality and tissue morphology in the ex vivo lung perfusion (EVLP) era of lung transplantation.
气道树中有生命吗?肺移植的离体肺灌注(EVLP)时代支气管细胞活力和组织形态的初步研究。
Artif Organs. 2022 Nov;46(11):2234-2243. doi: 10.1111/aor.14342. Epub 2022 Jun 28.
4
Current trends in candidate selection, contraindications, and indications for lung transplantation.肺移植候选者选择、禁忌证及适应证的当前趋势
J Thorac Dis. 2021 Nov;13(11):6514-6527. doi: 10.21037/jtd-2021-09.
5
Porcine slaughterhouse lungs for ex vivo lung perfusion - a pilot project.用于体外肺灌注的猪屠宰场肺脏——一个试点项目。
Am J Transl Res. 2020 Oct 15;12(10):6455-6463. eCollection 2020.
6
Machine perfusion of thoracic organs.胸部器官的机器灌注
J Thorac Dis. 2018 Apr;10(Suppl 8):S910-S923. doi: 10.21037/jtd.2018.02.85.