Strategies of clinical research on neurobiological determinants of psychosis.

Despite great efforts in clinical psychiatric research in the last decades, many simple questions still remain open. Present day clinical practice still lacks theoretically founded and generally accepted therapeutic rules, especially in the individual case. Similarly, in basic research we are far from understanding the etiopathogenetics of psychiatric illness. From summarizing some aspects of previous research strategies and results in neurobiological determinants in psychosis, future research strategies are outlined, which already have proven successful and thus should be pursued more rigorously. Not least because of general limited research capacities with respect to time and costs, future research has to proceed economically, i.e. guided by clear strategies.