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连续100例机器人辅助经裂孔食管切除术的手术及生存结果

Operative and survival outcomes in a series of 100 consecutive cases of robot-assisted transhiatal esophagectomies.

作者信息

Dunn D H, Johnson E M, Anderson C A, Krueger J L, DeFor T E, Morphew J A, Banerji N

机构信息

VPCI Esophageal and Gastric Cancer Program.

VPCI Research.

出版信息

Dis Esophagus. 2017 Oct 1;30(10):1-7. doi: 10.1093/dote/dox045.

Abstract

Robotic-assisted transhiatal esophagectomy (RATE) is a technically complex procedure with potential for improved postoperative outcomes. In this report, we describe our experience with RATE in a large case series. A retrospective review was conducted to collect clinical, outcomes, and survival data for 100 consecutive patients with esophageal cancer (n = 98) and benign (n = 2) conditions undergoing RATE between March 2007 and December 2014. Progression-free (PFS) and overall (OS) survival were estimated using the Kaplan-Meier curves with comparisons by log-rank tests. Median operative time and estimated blood loss were 264 minutes and 75 mL, respectively. Median intensive care unit stay was 1 day and median length of hospital stay was 8 days. Postoperative complications commonly observed were nonmalignant pleural effusion (38%) and recurrent laryngeal nerve injury (33%); 30 day mortality rate was 2%. Median number of lymph nodes removed during RATE was 17 and R0 resection was achieved in 97.8% patients. At the end of the median follow-up period of 27.7 months, median PFS was 41 months and median OS was 54 months. 1-year and 3-year PFS rates were 82% (95% CI, 75%-89%) and 53% (95% CI, 42%-62%), respectively, and OS rates were 95% (95% CI, 91%-99%) and 57% (95% CI, 46%-67%). In our experience, RATE is an effective and safe oncologic surgical procedure in a carefully selected group of patients with acceptable operative time, minimal blood loss, standard postoperative morbidity and adequate PFS and OS profiles.

摘要

机器人辅助经裂孔食管切除术(RATE)是一种技术复杂的手术,具有改善术后结局的潜力。在本报告中,我们描述了在一个大型病例系列中开展RATE的经验。进行了一项回顾性研究,以收集2007年3月至2014年12月期间连续100例接受RATE的食管癌患者(n = 98)和良性疾病患者(n = 2)的临床、结局和生存数据。采用Kaplan-Meier曲线估计无进展生存期(PFS)和总生存期(OS),并通过对数秩检验进行比较。中位手术时间和估计失血量分别为264分钟和75毫升。重症监护病房中位住院时间为1天,住院中位时间为8天。常见的术后并发症为非恶性胸腔积液(38%)和喉返神经损伤(33%);30天死亡率为2%。RATE期间切除淋巴结的中位数量为17个,97.8%的患者实现了R0切除。在中位随访期27.7个月结束时,中位PFS为41个月,中位OS为54个月。1年和3年PFS率分别为82%(95%CI,75%-89%)和53%(95%CI,42%-62%),OS率分别为95%(95%CI,91%-99%)和57%(95%CI,46%-67%)。根据我们的经验,RATE在精心挑选的患者群体中是一种有效且安全的肿瘤外科手术,手术时间可接受,失血量少,术后发病率标准,PFS和OS情况良好。

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