Vollmer E, Roessner A, Lipecki K H, Zwadlo G, Hagemeier H H, Grundmann E
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;53(1):58-65.
The etiology of aneurysmal bone cyst is still unknown. Most theories of the histogenesis of this lesion assume a vascular origin and speculation has focused on the characteristic pseudoendothelial lining of the cyst walls. In the present study, this structure has been subjected to enzyme histochemical, electron microscopical, and immunohistochemical investigation. Of the enzymes tested only alkaline phosphatase was present in the cyst lining. Electron microscopy revealed fibroblast-like cells covering the walls of cystic cavities, but no genuine endothelium, basement membranes or pericytes were identified. For the immunohistochemical studies a panel of poly- and monoclonal antibodies against HLA-DR antigens, mature and immature macrophages/histiocytes, smooth muscle fibers and endothelial cells, as well as the lectin Ulex europaeus I agglutinin were used. None of these markers demonstrated the presupposed vascular characteristics in the cells constituting the pseudoendothelial lining of the cyst walls. Despite current theories to the contrary, it was concluded that aneurysmal bone cyst is unlikely to originate from the vascular system, and that a new concept of its pathogenesis must be sought.
动脉瘤样骨囊肿的病因仍不清楚。关于该病变组织发生的大多数理论都认为其起源于血管，推测集中在囊肿壁的特征性假内皮衬里。在本研究中，对这种结构进行了酶组织化学、电子显微镜和免疫组织化学研究。在所检测的酶中，只有碱性磷酸酶存在于囊肿衬里。电子显微镜显示成纤维细胞样细胞覆盖囊性腔壁，但未发现真正的内皮、基底膜或周细胞。免疫组织化学研究使用了一组针对HLA-DR抗原、成熟和未成熟巨噬细胞/组织细胞、平滑肌纤维和内皮细胞的多克隆和单克隆抗体，以及凝集素荆豆凝集素I。这些标志物均未在构成囊肿壁假内皮衬里的细胞中显示出预设的血管特征。尽管目前的理论与此相反，但得出的结论是，动脉瘤样骨囊肿不太可能起源于血管系统，必须寻求其发病机制的新概念。
