Aho H J, Aho A J, Pelliniemi L J, Ekfors T O, Foidart J M
Histopathology. 1985 Apr;9(4):381-7. doi: 10.1111/j.1365-2559.1985.tb02822.x.
The surface of the large cystic spaces and dilated blood vessels in seven cases of aneurysmal bone cysts was studied. The endothelium of the blood vessels was surrounded by a layer of collagen types IV and V, and the endothelial cells contained factor VIII related antigen demonstrated by the peroxidase anti-peroxidase technique. Some blood vessels were dilated resembling small aneurysmal spaces. The visible surfaces of the aneurysmal spaces were devoid of collagen types IV and V, and of factor VIII related antigen. Ultrastructural analysis of paraffin embedded sections did not show the characteristic fine structural features of endothelium covering the aneurysmal spaces. It is concluded that the large spaces in aneurysmal bone cysts are devoid of basement membranes and endothelial cells. The absence of endothelium may explain the abundance of haemorrhages in these lesions. Immunocytochemical demonstration of endothelial antigen provides a valuable tool for the differential diagnosis between aneurysmal bone cysts and vascular tumours.
对7例动脉瘤样骨囊肿的大囊腔和扩张血管表面进行了研究。血管内皮被一层IV型和V型胶原所包绕，采用过氧化物酶抗过氧化物酶技术显示内皮细胞含有VIII因子相关抗原。一些血管扩张，类似小动脉瘤腔。动脉瘤腔的可见表面缺乏IV型和V型胶原以及VIII因子相关抗原。对石蜡包埋切片的超微结构分析未显示覆盖动脉瘤腔的内皮细胞的特征性精细结构特征。结论是动脉瘤样骨囊肿中的大腔隙缺乏基底膜和内皮细胞。内皮细胞的缺失可能解释了这些病变中出血的丰富情况。内皮抗原的免疫细胞化学显示为动脉瘤样骨囊肿与血管肿瘤的鉴别诊断提供了一种有价值的工具。
