Lyrenäs S, Nyberg F, Lutsch H, Lindberg B, Terenius L
Acta Endocrinol (Copenh). 1987 Jun;115(2):253-8.
Cerebrospinal fluid (CSF) levels of dynorphin A and beta-endorphin were measured by radioimmunoassay in 62 primiparae in term pregnancy before onset of labour. In 50 of these women acupuncture (AP) treatment was given in an antenatal preparation procedure. In 15 of the AP-treated women, CSF samples were further obtained six months after delivery. Median values for dynorphin A were 7.5 pmol/l in AP-treated women and 6.4 pmol/l in non-treated controls. The puerperal median value for dynorphin A was 7.6 pmol/l. Median values for beta-endorphin were 7.1 pmol/l in AP-treated women and 5.7 pmol/l in non-treated controls. The median beta-endorphin value after delivery was 7.3 pmol/l. There was no significant difference in CSF dynorphin A or beta-endorphin levels between the AP-treated women and non-treated controls in late pregnancy. Consequently, the present study does not support the theory of a positive influence on either the dynorphin or the beta-endorphin system by manual AP. Within subject comparisons of dynorphin-A and beta-endorphin failed to indicate any significant trend in samples obtained in late pregnancy and 6 months after delivery, and there was no increased activity in either the dynorphin or the beta-endorphin system in late pregnancy, as reflected by CSF levels.
采用放射免疫分析法测定了62例足月妊娠初产妇临产前脑脊液中强啡肽A和β-内啡肽的水平。其中50名妇女在产前准备过程中接受了针刺治疗。在15名接受针刺治疗的妇女中，产后6个月进一步采集了脑脊液样本。接受针刺治疗的妇女中强啡肽A的中位数为7.5 pmol/l，未治疗的对照组为6.4 pmol/l。产后强啡肽A的中位数为7.6 pmol/l。接受针刺治疗的妇女中β-内啡肽的中位数为7.1 pmol/l，未治疗的对照组为5.7 pmol/l。产后β-内啡肽的中位数为7.3 pmol/l。妊娠晚期接受针刺治疗的妇女与未治疗的对照组之间，脑脊液中强啡肽A或β-内啡肽水平无显著差异。因此，本研究不支持手法针刺对强啡肽或β-内啡肽系统有积极影响的理论。对强啡肽A和β-内啡肽进行的个体内比较未能显示妊娠晚期和产后6个月采集的样本中有任何显著趋势，并且从脑脊液水平反映出妊娠晚期强啡肽或β-内啡肽系统均无活性增加。
