Kofinas G D, Kofinas A D, Pyrgerou M, Reyes F I
Obstet Gynecol. 1987 Jun;69(6):945-7.
To define the relationship between amniotic fluid concentrations of beta-endorphin immunoreactivity and onset of parturition, we measured this opioid in samples obtained during cesarean section at term. A total of 27 women were studied, 14 without labor and 13 in early labor. Mean (+/- SE) amniotic fluid beta-endorphin levels were significantly lower in patients in labor than in those not in labor (3.2 +/- 0.05 versus 8.4 +/- 1.0 fmol/mL). The mean beta-endorphin level (21.1 +/- 4.2 fmol/mL) in other amniotic fluid samples obtained during the second trimester of pregnancy was significantly higher than mean values at term. These differences in amniotic fluid beta-endorphin levels may support the theory of an opioid mechanism involved in parturition.
为了确定羊水中β-内啡肽免疫反应性浓度与分娩发动之间的关系，我们在足月剖宫产时采集的样本中测量了这种阿片类物质。共研究了27名女性，其中14名未临产，13名处于分娩早期。临产患者羊水中β-内啡肽水平的均值（±标准误）显著低于未临产患者（3.2±0.05对8.4±1.0 fmol/mL）。在妊娠中期采集的其他羊水样本中，β-内啡肽平均水平（21.1±4.2 fmol/mL）显著高于足月时的均值。羊水中β-内啡肽水平的这些差异可能支持了分娩过程中存在阿片类物质机制的理论。
