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源于复合痣的小儿结膜黑色素瘤。

Pediatric conjunctival melanoma arising from a compound nevus.

作者信息

Liu Katy C, Mruthyunjaya Prithvi, Proia Alan D, Vora Gargi K

机构信息

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Ophthalmology, Stanford University Medical Center, Palo Alto, California.

出版信息

J AAPOS. 2017 Oct;21(5):416-418. doi: 10.1016/j.jaapos.2017.04.014. Epub 2017 Aug 30.

Abstract

We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with fine surrounding vessels. Enhanced depth imaging-optical coherence tomography showed no invasion into the sclera. The patient underwent excisional biopsy, and histopathology revealed conjunctival melanoma arising from a nevus with malignant cells that stained positively with markers HMB-45 and Ki-67. Systemic workup was negative for metastatic disease. Conjunctival nevi are the most common melanocytic conjunctival lesions in children and generally demonstrate physiologic growth during adolescence. Thus, there may be a greater risk of misdiagnosis of conjunctival melanoma in a child.

摘要

我们报告了一例罕见的9岁女孩结膜黑色素瘤病例,该女孩左眼出现结膜病变,其生长情况由患者照片记录。检查发现颞侧角膜缘有一个隆起的色素沉着病变,周围有细小血管。增强深度成像光学相干断层扫描显示未侵犯巩膜。患者接受了切除活检,组织病理学显示结膜黑色素瘤起源于痣,恶性细胞对HMB-45和Ki-67标记物呈阳性染色。全身检查未发现转移性疾病。结膜痣是儿童最常见的结膜黑素细胞病变,通常在青春期呈现生理性生长。因此,儿童结膜黑色素瘤的误诊风险可能更高。

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