Roccatello D, Coppo R, Martina G, Rollino C, Basolo B, Frattasio C, Fasano M E, Amoroso A, Picciotto G, Bajardi P
Am J Nephrol. 1987;7(2):85-92. doi: 10.1159/000167441.
The Fc-receptor function of the mononuclear phagocyte system was examined in 30 patients affected by multisystem diseases with glomerular involvement by measuring the immune clearance of IgG-sensitized autologous red blood cells in vivo and the immune phagocytosis of monocytes in vitro. Patients studied in the phase of clinically active renal disease showed a significantly reduced Fc-receptor function by both in vivo (p less than 0.001) and in vitro (p = 0.003) assays, as compared to those studied during an inactive phase. Though the nature of the defect remains uncertain, it appears to be related to the active phase of the renal disease as also confirmed by the analysis of individual cases studied longitudinally.
通过在体内测量IgG致敏的自体红细胞的免疫清除率以及在体外测量单核细胞的免疫吞噬作用，对30例患有累及肾小球的多系统疾病的患者的单核吞噬细胞系统的Fc受体功能进行了检测。与处于非活动期的患者相比，处于临床活动性肾脏疾病阶段的患者通过体内（p<0.001）和体外（p=0.003）检测均显示Fc受体功能显著降低。尽管缺陷的性质仍不确定，但纵向研究的个体病例分析也证实，它似乎与肾脏疾病的活动期有关。
