Vernet O, Nacht C A, Christin L, Schutz Y, Danforth E, Jequier E
Am J Physiol. 1987 Jul;253(1 Pt 1):E65-71. doi: 10.1152/ajpendo.1987.253.1.E65.
Continuous respiratory exchange measurements were performed in nine obese and eight lean women for 1 h before, 3 h during, and 1 h after the intravenous administration of a nutrient mixture infused at twice the postabsorptive resting energy expenditure (REE). This experiment was conducted without or with beta-adrenergic blockade (iv propranolol). Propranolol administration did not change the postabsorptive REE [i.e., 1.03 +/- 0.07 before vs. 1.01 +/- 0.02 kcal/min after administration in lean women and 1.16 +/- 0.04 vs. 1.15 +/- 0.03 kcal/min (NS) in obese women]. The mean overall thermogenic response expressed as a percentage of the infused energy was similar in both groups and was not significantly blunted after propranolol infusion [6.9 +/- 0.4 vs. 5.9 +/- 0.6% in the lean women and 7.5 +/- 0.5 vs. 7.1 +/- 0.6% (NS) in the obese women]. During beta-adrenergic blockade the rate of lipid oxidation decreased in the lean group but was unchanged in the obese group and the glycemic response to nutrient administration was significantly higher in both groups than without propranolol. It is concluded that beta-adrenergic blockade has no effect on REE and on intravenous nutrient-induced thermogenesis in both lean and obese women.
对9名肥胖女性和8名瘦女性进行持续呼吸交换测量，在静脉注射一种营养混合物前1小时、注射期间3小时以及注射后1小时进行测量，该营养混合物的输注速度为吸收后静息能量消耗（REE）的两倍。本实验在无β-肾上腺素能阻滞剂或有β-肾上腺素能阻滞剂（静脉注射普萘洛尔）的情况下进行。普萘洛尔给药并未改变吸收后的REE[即瘦女性给药前为1.03±0.07千卡/分钟，给药后为1.01±0.02千卡/分钟；肥胖女性给药前为1.16±0.04千卡/分钟，给药后为1.15±0.03千卡/分钟（无显著性差异）]。两组中以输注能量的百分比表示的平均总体产热反应相似，且在输注普萘洛尔后并未显著减弱[瘦女性中为6.9±0.4%对5.9±0.6%；肥胖女性中为7.5±0.5%对7.1±0.6%（无显著性差异）]。在β-肾上腺素能阻滞剂作用期间，瘦女性组的脂质氧化速率降低，但肥胖女性组未发生变化，且两组对营养物质给药的血糖反应均显著高于未使用普萘洛尔时。得出的结论是，β-肾上腺素能阻滞剂对瘦女性和肥胖女性的REE以及静脉营养诱导的产热均无影响。
