Vernet O, Christin L, Schutz Y, Danforth E, Jéquier E
Am J Clin Nutr. 1986 Feb;43(2):194-209. doi: 10.1093/ajcn/43.2.194.
Continuous respiratory-exchange measurements were performed on ten moderately obese and ten lean young women for 1 h before, 3 h during, and 3 h after either parenteral (IV) or intragastric (IG) administration of a nutrient mixture infused at twice the postabsorptive, resting energy expenditure (REE). REE rose significantly from 0.98 +/- 0.02 to 1.13 +/- 0.03 kcal/min (IV) and from 0.99 +/- 0.02 to 1.13 +/- 0.02 kcal/min (IG) in the lean group; from 1.10 +/- 0.02 to 1.27 +/- 0.03 kcal/min (IV) and from 1.11 +/- 0.02 to 1.29 +/- 0.03 (IG) in the obese group. These increases resulted in similar nutrient-induced thermogenesis of 10.0 +/- 0.7% (IV) and 9.3 +/- 0.9% (IG) in the lean group; of 9.2 +/- 0.7% (IV) and 10.1 +/- 0.8% (IG) in the obese. Nutrient utilization was comparable in both groups and in both routes of administration, although the response time to IG feeding was delayed. These results showed no significant difference in both the thermogenic response and nutrient utilization between moderately obese and control groups using acute IV or IG feeding.
对10名中度肥胖和10名体重正常的年轻女性进行持续呼吸交换测量，在经静脉（IV）或胃内（IG）给予营养混合物前1小时、给予期间3小时以及给予后3小时进行测量，营养混合物的输注速度为基础静息能量消耗（REE）的两倍。在体重正常组中，REE从0.98±0.02千卡/分钟显著升至1.13±0.03千卡/分钟（IV）以及从0.99±0.02千卡/分钟升至1.13±0.02千卡/分钟（IG）；在肥胖组中，REE从1.10±0.02千卡/分钟升至1.27±0.03千卡/分钟（IV）以及从1.11±0.02千卡/分钟升至1.29±0.03千卡/分钟（IG）。这些升高导致体重正常组中营养诱导的产热相似，分别为10.0±0.7%（IV）和9.3±0.9%（IG）；肥胖组中分别为9.2±0.7%（IV）和10.1±0.8%（IG）。两组在两种给药途径下的营养利用率相当，尽管对IG喂养的反应时间有所延迟。这些结果表明，使用急性IV或IG喂养时，中度肥胖组和对照组在产热反应和营养利用率方面均无显著差异。
