精神分裂症患者对抗精神病药物缺乏后天耐受性。
Absence of acquired tolerance to neuroleptics in schizophrenic patients.
作者信息
Palmstierna T, Wistedt B
出版信息
Am J Psychiatry. 1987 Aug;144(8):1084-5. doi: 10.1176/ajp.144.8.1084.
PMID:2886065
Abstract
Development of increased tolerance to neuroleptics was investigated in 38 neuroleptic-respondent schizophrenic patients. At 5- or 8-year follow-up, clinical global assessments were related to changes in neuroleptic doses. In 93% of the patients gradually increasing tolerance could be excluded.
摘要
对38名对神经阻滞剂有反应的精神分裂症患者增加对神经阻滞剂耐受性的情况进行了研究。在5年或8年的随访中，临床综合评估与神经阻滞剂剂量的变化相关。93%的患者可排除逐渐增加耐受性的情况。
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