Lymphoid follicles in children with -negative gastritis.

PURPOSE

The prevalence of gastritis has been declining, whereas -negative gastritis has become more common. We evaluated chronic gastritis in children with regard to status and celiac disease (CD).

PATIENTS AND METHODS

Demographic, clinical, endoscopic, and histologic features of children who underwent elective esophagogastroduodenoscopy were reviewed retrospectively. Gastric biopsies from the antrum and corpus of the stomach were graded using the Updated Sydney System. presence was defined by hematoxylin and eosin, Giemsa, or immunohistochemical staining and urease testing.

RESULTS

A total of 184 children (61.9% female) met the study criteria with a mean age of 10 years. A total of 122 (66.3%) patients had chronic gastritis; 74 (60.7%) were -negative. Children with -negative gastritis were younger (=0.003), were less likely to present with abdominal pain (=0.02), and were mostly of non-Arabic origin (=0.011). Nodular gastritis was found to be less prevalent in -negative gastritis (6.8%) compared with -positive gastritis (35.4%, <0.001). The grade of mononuclear infiltrates and neutrophil density was more severe in the -positive group (<0.001). Pan-gastritis and lymphoid follicles were associated most commonly with . Although less typical, lymphoid follicles were demonstrated in 51.3% of -negative patients. The presence or absence of CD was not associated with histologic findings in -negative gastritis.

CONCLUSION

Our findings suggest that lymphoid follicles are a feature of -negative gastritis in children independent of their CD status.