Noble D W, Smith K J, Dundas C R
Br J Anaesth. 1987 Jun;59(6):735-7. doi: 10.1093/bja/59.6.735.
The effects of two histamine H-2 antagonists, cimetidine and ranitidine, on the elimination of bupivacaine were studied in four male volunteers. The cimetidine-treated group demonstrated a statistically significant decrease in clearance of bupivacaine. These results indicate that concomitant administration of cimetidine and bupivacaine may increase the likelihood of toxicity of the latter agent.
在四名男性志愿者中研究了两种组胺H-2拮抗剂西咪替丁和雷尼替丁对布比卡因消除的影响。西咪替丁治疗组的布比卡因清除率出现了具有统计学意义的下降。这些结果表明，同时给予西咪替丁和布比卡因可能会增加后者的毒性发生可能性。
