O'Sullivan G M, Smith M, Morgan B, Brighouse D, Reynolds F
Department of Anaesthetics, St Thomas' Hospital, London.
Anaesthesia. 1988 Feb;43(2):93-5. doi: 10.1111/j.1365-2044.1988.tb05471.x.
The effect of the H2 receptor antagonists cimetidine and ranitidine on bupivacaine clearance was assessed in women scheduled to undergo elective Caesarean section under epidural anaesthesia. Thirty-six women were randomly allocated to receive either no medication, cimetidine 400 mg or ranitidine 150 mg on the night prior to and on the morning of surgery. No significant difference was found between the peak bupivacaine levels: the mean (SD) values were 0.74 (0.17) microgram/ml, 0.81 (0.38) microgram/ml and 0.70 (0.24) microgram/ml in the control, cimetidine and ranitidine groups, respectively. Similarly, the H2 receptor antagonists did not alter the plasma bupivacaine against time curves, half-life or bupivacaine clearance in the three groups studied.
在计划接受硬膜外麻醉下择期剖宫产的女性中，评估了H2受体拮抗剂西咪替丁和雷尼替丁对布比卡因清除率的影响。36名女性被随机分配，在手术前一晚和手术当天早晨分别接受无药物治疗、400毫克西咪替丁或150毫克雷尼替丁。布比卡因峰值水平之间未发现显著差异：对照组、西咪替丁组和雷尼替丁组的平均（标准差）值分别为0.74（0.17）微克/毫升、0.81（0.38）微克/毫升和0.70（0.24）微克/毫升。同样，在所研究的三组中，H2受体拮抗剂并未改变血浆布比卡因浓度随时间的曲线、半衰期或布比卡因清除率。
