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创建癌症精准医学国家战略的提案:SEOM、SEAP 和 SEFH 的立场声明。

Proposal for the creation of a national strategy for precision medicine in cancer: a position statement of SEOM, SEAP, and SEFH.

机构信息

Medical Oncology, Ramón y Cajal University Hospital, IRYCIS, University of Alcalá, Madrid, Spain.

Pharmacy, Clínica Universidad de Navarra, Working Group PkGen from the SEFH, Pamplona, Spain.

出版信息

Clin Transl Oncol. 2018 Apr;20(4):443-447. doi: 10.1007/s12094-017-1740-0. Epub 2017 Aug 31.

Abstract

Precision medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Precision medicine is transforming clinical and biomedical research, as well as health care itself from a conceptual, as well as a methodological viewpoint, providing extraordinary opportunities to improve public health and lower the costs of the healthcare system. However, the implementation of precision medicine poses ethical-legal, regulatory, organizational, and knowledge-related challenges. Without a national strategy, precision medicine, which will be implemented one way or another, could take place without the appropriate planning that can guarantee technical quality, equal access of all citizens to the best practices, violating the rights of patients and professionals, and jeopardizing the solvency of the healthcare system. With this paper from the Spanish Societies of Medical Oncology, Pathology, and Hospital Pharmacy, we highlight the need to institute a consensual national strategy for the development of precision medicine in our country, review the national and international context, comment on the opportunities and challenges for implementing precision medicine, and outline the objectives of a national strategy on precision medicine in cancer.

摘要

精准医学是一种新兴的疾病治疗和预防方法,考虑到每个人的基因、环境和生活方式的个体差异。精准医学正在从概念和方法学的角度改变临床和生物医学研究以及医疗保健本身,为改善公共卫生和降低医疗保健系统成本提供了非凡的机会。然而,精准医学的实施带来了伦理法律、监管、组织和知识相关的挑战。如果没有国家战略,精准医学无论以何种方式实施,都可能在没有适当规划的情况下进行,无法保证技术质量、所有公民平等获得最佳实践的机会,从而侵犯患者和专业人员的权利,并危及医疗保健系统的偿付能力。本文来自西班牙医学肿瘤学、病理学和医院药学学会,强调有必要在我国制定一项共识性的精准医学国家战略,审查国内外背景,讨论实施精准医学的机遇和挑战,并概述癌症精准医学国家战略的目标。

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