Kunts T A, Mikhaylova E S, Marinkin I O, Varaksin N A, Autenshlyus A I, Lyakhovich V V
Novosibirsk State Medical University, Novosibirsk, 630091, Russia.
Research Institute of Molecular Biology and Biophysics, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, 630117, Russia.
Dokl Biol Sci. 2017 Jul;475(1):172-174. doi: 10.1134/S0012496617040020. Epub 2017 Sep 1.
Dependence of cytokine pattern in the tumor supernatant obtained after cultivation of biopsy samples-on the patients' age was evaluated among patients with invasive ductal carcinoma of the breast. An increase in VEGF and IL-6 production in a group of younger patients was observed. An increase only in interferon γ concentration was revealed in the supernatants of the tumor after addition of polyclonal activators to the culture medium. This result indicates likely secretion of interferon γ in younger patients. The relation among the production of angiogenic factors by tumor cells, age of the patients, and presence or absence of lymph node metastases shows that in such studies, patients have to be stratified by age.
在乳腺浸润性导管癌患者中，评估了活检样本培养后肿瘤上清液中细胞因子模式对患者年龄的依赖性。观察到一组年轻患者中VEGF和IL-6产生增加。向培养基中添加多克隆激活剂后，肿瘤上清液中仅干扰素γ浓度升高。这一结果表明年轻患者可能分泌干扰素γ。肿瘤细胞产生血管生成因子、患者年龄以及有无淋巴结转移之间的关系表明，在此类研究中，必须按年龄对患者进行分层。
