Adebayo G I, Oyenuga A B, Mabadeje A F
Clin Exp Pharmacol Physiol. 1987 Feb;14(2):103-9. doi: 10.1111/j.1440-1681.1987.tb00963.x.
The effect of beta-adrenoceptor blockers on the absorption and elimination of the diuretic chlorothiazide was studied in healthy subjects. A week of pretreatment with either pindolol (10 mg twice daily) or propranolol (80 mg twice daily) resulted in significant reduction in 36 h mean cumulative urinary recovery of chlorothiazide in two groups of six subjects compared with a control (untreated) group. A week of pretreatment with atenolol (100 mg daily) did not significantly alter 36 h cumulative urinary excretion in another group of six subjects. None of the beta-blockers significantly changed chlorothiazide half-life. It is suggested that the non-selective (as opposed to the cardioselective) beta-blockers reduce chlorothiazide absorption by the mechanism(s) discussed.
在健康受试者中研究了β-肾上腺素受体阻滞剂对利尿剂氯噻嗪吸收和消除的影响。与未治疗的对照组相比，两组各6名受试者分别用吲哚洛尔（每日2次，每次10mg）或普萘洛尔（每日2次，每次80mg）预处理1周后，氯噻嗪36小时平均累积尿回收率显著降低。另一组6名受试者用阿替洛尔（每日100mg）预处理1周后，36小时累积尿排泄量无显著变化。所有β-阻滞剂均未显著改变氯噻嗪的半衰期。提示非选择性（与心脏选择性相对）β-阻滞剂通过所讨论的机制降低氯噻嗪的吸收。
