Chowdhry Amit K, Fung Chunkit, Chowdhry Varun K, Bergsma Derek, Dhakal Sughosh, Constine Louis S, Milano Michael T
a University of Rochester School of Medicine , Rochester , NY , USA.
b University of Rochester Medical Center , Division of Medical Oncology , Rochester , NY , USA.
Leuk Lymphoma. 2018 May;59(5):1180-1187. doi: 10.1080/10428194.2017.1369063. Epub 2017 Sep 1.
Hodgkin lymphoma (HL) survivors are at increased risk of thyroid cancer (TC). We sought to determine whether increased risks of high-risk pathology or mortality are seen with thyroid cancer after HL (HL-TC) compared with first primary thyroid cancer (TC-1). From the Surveillance, Epidemiology and End Results (SEER) registry, we compared patient and tumor characteristics as well as survival outcomes between HL-TC and TC-1 and fit a multivariable Cox model to assess for a possible association between HL history and overall survival after TC. Among 139,297 TC-1 and 174 HL-TC patients, history of HL was not associated with anaplastic or sarcoma TC. Multivariable analyzes showed that history of HL was not associated with a difference in risk of death after TC (hazard ratio: 0.96, 95% confidence interval: (0.81, 1.13), p = .61). Despite a significantly increased risk of TC among HL survivors, prior HL is not associated with more aggressive pathologic subtypes or worse prognosis.
霍奇金淋巴瘤（HL）幸存者患甲状腺癌（TC）的风险增加。我们试图确定与原发性甲状腺癌（TC-1）相比，HL后发生的甲状腺癌（HL-TC）是否存在高风险病理或死亡风险增加的情况。通过监测、流行病学和最终结果（SEER）登记处，我们比较了HL-TC和TC-1患者的特征、肿瘤特征以及生存结果，并拟合了多变量Cox模型，以评估HL病史与TC后总生存之间的可能关联。在139297例TC-1患者和174例HL-TC患者中，HL病史与间变性或肉瘤样TC无关。多变量分析显示，HL病史与TC后死亡风险差异无关（风险比：0.96，95%置信区间：(0.81, 1.13)，p = 0.61）。尽管HL幸存者患TC的风险显著增加，但既往HL与更具侵袭性的病理亚型或更差的预后无关。
