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异时性多原发性前列腺癌和淋巴瘤：一例报告。

Heterochronous multiple primary prostate cancer and lymphoma: A case report.

作者信息

Liang Jin-Long, Bu Yu-Qing, Peng Li-Li, Zhang Hong-Zhen

机构信息

Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China.

出版信息

World J Clin Cases. 2024 Mar 6;12(7):1333-1338. doi: 10.12998/wjcc.v12.i7.1333.

DOI:10.12998/wjcc.v12.i7.1333
PMID:38524523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955537/
Abstract

BACKGROUND

Multiple primary malignant tumors (MPMTs) are rare type of cancer, especially when solid tumors are the first and lymphoma is the second primary malignancy. We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma (DLBCL).

CASE SUMMARY

We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide (50 mg per day) and an extended-release implant of goserelin (1/28 d). Seven years later, rectal DLBCL with lung metastases was found.

CONCLUSION

Although rare, the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.

摘要

背景

多原发性恶性肿瘤（MPMTs）是一种罕见的癌症类型，尤其是当实体瘤为首发原发恶性肿瘤且淋巴瘤为第二原发恶性肿瘤时。我们报告一例患有异时性MPMTs的患者，其肿瘤包括前列腺癌和直肠弥漫性大B细胞淋巴瘤（DLBCL）。

病例摘要

我们报告一名77岁男性患者，诊断为前列腺癌，接受了放射治疗以及为期一年的内分泌治疗，使用比卡鲁胺（每日50毫克）和戈舍瑞林缓释植入剂（每28天1次）。七年后，发现患有伴有肺转移的直肠DLBCL。

结论

尽管罕见，但前列腺癌合并DLBCL双原发性癌症的可能性有助于深入理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/10955537/4e490a05a686/WJCC-12-1333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/10955537/9d282ba3ad7d/WJCC-12-1333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/10955537/4e490a05a686/WJCC-12-1333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/10955537/9d282ba3ad7d/WJCC-12-1333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/10955537/4e490a05a686/WJCC-12-1333-g002.jpg

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本文引用的文献

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Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches.前列腺癌综述：遗传学、诊断、治疗选择和替代方法。
Molecules. 2022 Sep 5;27(17):5730. doi: 10.3390/molecules27175730.
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Prostate radiotherapy and the risk of secondary rectal cancer-a meta-analysis.前列腺放射治疗与继发直肠癌风险：一项荟萃分析。
Int J Colorectal Dis. 2022 Feb;37(2):437-447. doi: 10.1007/s00384-021-04075-6. Epub 2022 Jan 17.
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Primary biliary non-Hodgkin's lymphoma: A case report.原发性胆汁性非霍奇金淋巴瘤：一例报告。
Medicine (Baltimore). 2021 Jun 4;100(22):e26110. doi: 10.1097/MD.0000000000026110.
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Diffuse Large B-Cell Lymphoma.弥漫性大 B 细胞淋巴瘤。
N Engl J Med. 2021 Mar 4;384(9):842-858. doi: 10.1056/NEJMra2027612.
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
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Multiple Primary Malignant Tumors - A Clinical Analysis of 15,321 Patients with Malignancies at a Single Center in China.多原发性恶性肿瘤——中国某单中心15321例恶性肿瘤患者的临床分析
J Cancer. 2018 Jul 16;9(16):2795-2801. doi: 10.7150/jca.25482. eCollection 2018.
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A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma.一项基于人群的霍奇金淋巴瘤后发生第二原发性甲状腺癌患者的预后和生存情况研究。
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