Department of Chemistry, Indian Institute of Technology Roorkee , Roorkee 247667, Uttarakhand, India.
J Org Chem. 2017 Sep 15;82(18):9367-9383. doi: 10.1021/acs.joc.7b00684. Epub 2017 Sep 1.
A rapid, efficient, and metal-free Lewis acid-mediated methodology has been developed for the site-selective synthesis of unsymmetrical oxygenated biaryls. This simple and efficient methodology furnished highly oxygenated and functionalized unsymmetrical biaryls in good to excellent yields by the direct oxidative coupling of electron-rich arenes to the α-position of carbonyl functionality of in situ generated masked benzoquinones.
一种快速、高效且无需金属的路易斯酸介导方法已经被开发出来，用于不对称氧代联芳烃的选择性合成。这种简单高效的方法通过富电子芳环与原位生成的掩蔽苯醌的羰基α-位的直接氧化偶联，以良好至优秀的收率得到了高度氧化和官能化的不对称氧代联芳烃。
